The blood peptidome: A higher dimension of information content for cancer biomarker discovery

Emanuel F. Petricoin; Claudio Belluco; Robyn P. Araujo; Lance A. Liotta

doi:10.1038/nrc2011

The blood peptidome: A higher dimension of information content for cancer biomarker discovery

Emanuel F. Petricoin^*, Claudio Belluco, Robyn P. Araujo, Lance A. Liotta

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

311 Scopus citations

Abstract

The low-molecular-weight range of the circulatory proteome is termed the 'peptidome', and could be a rich source of cancer-specific diagnostic information because it is a 'recording' of the cellular and extracellular enzymatic events that take place at the level of the cancer-tissue microenvironment. This new information archive seems to mainly exist in vivo, bound to high-abundance proteins such as albumin.Measuring panels of peptidome markers might be more sensitive and specific than conventional biomarker approaches. We discuss the advantages and disadvantages of various methods for studying the peptidome.

Original language	English
Pages (from-to)	961-967
Number of pages	7
Journal	Nature Reviews Cancer
Volume	6
Issue number	12
DOIs	https://doi.org/10.1038/nrc2011
State	Published - 9 Dec 2006
Externally published	Yes

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10.1038/nrc2011

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abstract = "The low-molecular-weight range of the circulatory proteome is termed the 'peptidome', and could be a rich source of cancer-specific diagnostic information because it is a 'recording' of the cellular and extracellular enzymatic events that take place at the level of the cancer-tissue microenvironment. This new information archive seems to mainly exist in vivo, bound to high-abundance proteins such as albumin.Measuring panels of peptidome markers might be more sensitive and specific than conventional biomarker approaches. We discuss the advantages and disadvantages of various methods for studying the peptidome.",

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AU - Araujo, Robyn P.

AU - Liotta, Lance A.

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AB - The low-molecular-weight range of the circulatory proteome is termed the 'peptidome', and could be a rich source of cancer-specific diagnostic information because it is a 'recording' of the cellular and extracellular enzymatic events that take place at the level of the cancer-tissue microenvironment. This new information archive seems to mainly exist in vivo, bound to high-abundance proteins such as albumin.Measuring panels of peptidome markers might be more sensitive and specific than conventional biomarker approaches. We discuss the advantages and disadvantages of various methods for studying the peptidome.

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The blood peptidome: A higher dimension of information content for cancer biomarker discovery

Abstract

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