The clinical application of monoclonal antibody therapies in renal transplantation

Kiran K. Dhanireddy, He Xu, Roslyn B. Mannon, Douglas A. Hale, Allan D. Kirk*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Monoclonal antibodies have become valuable tools for the precise clinical manipulation of the immune system. These highly specific proteins have proven their usefulness in both the treatment and prevention of organ transplant rejection. Indeed, they are the centrepieces of many evolving regimens designed to reduce or eliminate the need for chronic immunosuppression. This manuscript will review the monoclonal antibodies that have made their way into the clinic either as experimental therapies or approved drugs. It will provide a general overview of this class of agents and their mechanisms of action. Standard therapies and potential new applications will be described.

Original languageEnglish
Pages (from-to)23-37
Number of pages15
JournalExpert Opinion on Emerging Drugs
Issue number1
StatePublished - May 2004
Externally publishedYes


  • Immunosuppression
  • Monoclonal antibodies
  • Transplantation


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