The combination of PKM2 overexpression and M2 macrophages infiltration confers a poor prognosis for PDAC patients

Hai Hu, Wenzhi Tu, Yungu Chen, Ming Zhu, Huan Jin, Ting Huang, Zhengzhi Zou*, Qing Xia

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Macrophages play a critical role in the initiation and progression in various human solid tumors; however, their role and transformation in pancreatic ductal adenocarcinoma (PDAC) were still illusive. Here, immunohistochemistry was used to determine CD206 (specific marker of M2 macrophage) and PKM2 expression in PDAC tissues. Statistical analysis, such as Pearson χ2 test, Spearman's rank test, Kaplan-Meier and COX regression assay were used to evaluate their roles on PDAC prognosis. Data showed that both CD206 and PKM2 were elevated and responsible for a poor prognosis for PDAC. In addition, we showed that the two factors were positively correlated; co-overexpression of the two factors conferred the worst prognosis and functioned as an independent prognostic factor for the disease. Our data showed that M2 macrophage infiltration was correlated with PKM2 expression in PDAC cells. The two markers exerted synergistic effect on PDAC progression. Our results suggested dual-target inhibition M2 macrophage polarization and PKM2 expression of cancer cells might be novel approaches to treat PDAC.

Original languageEnglish
Pages (from-to)2022-2031
Number of pages10
JournalJournal of Cancer
Volume11
Issue number8
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • Macrophage
  • PDAC
  • PKM2
  • Prognosis

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