The composition and mechanical properties of porcine placental ECM from three different breeds

Héctor Capella-Monsonís, Madeline Cramer, Neill Turner, Janet Reing, Li Zhang, Russell T. Kronengold, Joseph Bartolacci, Stephen F. Badylak*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Biologic scaffolds are extensively used in various clinical applications such as musculotendinous reconstruction, hernia repair or wound healing. Biologic scaffolds used in these applications vary in species, breed and tissue of origin, and other variables that affect their properties. Decellularization and sterilization processes also determine the characteristics of these scaffolds. The goal of the present study is to compare the composition and mechanical properties of decellularized porcine placental scaffolds from three different porcine breeds: Landrace, York and Duroc. Placental extracellular matrix (ECM) scaffolds from the three porcine breeds preserved the amnion/chorion ECM structure and the basement membrane markers laminin and collagen type IV. ECM placental scaffolds showed similar contents of collagen, elastin and lipids, and minimal differences in glycosaminoglycans content. Mechanical properties from the three breeds ECM placental scaffolds were also similar and stable for 24 months. While this study serves as preliminary characterization of porcine ECM scaffolds, future studies will determine their compatibility and suitability for tissue engineering applications.

Original languageEnglish
Article number065012
JournalBiomedical physics & engineering express
Issue number6
StatePublished - Nov 2023
Externally publishedYes


  • ECM scaffold
  • decellularization
  • porcine placental ECM
  • regenerative medicine biomaterial


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