TY - JOUR
T1 - The contribution of adhesion signaling to lactogenesis
AU - Morrison, Bethanie
AU - Cutler, Mary Lou
N1 - Funding Information:
Acknowledgements The authors acknowledge support from the United States Military Cancer Institute.
PY - 2010/10
Y1 - 2010/10
N2 - The mammary gland undergoes hormonally controlled cycles of pubertal maturation, pregnancy, lactation, and involution, and these processes rely on complex signaling mechanisms, many of which are controlled by cell-cell and cell-matrix adhesion. The adhesion of epithelial cells to the extracellular matrix initiates signaling mechanisms that have an impact on cell proliferation, survival, and differentiation throughout lactation. The control of integrin expression on the mammary epithelial cells, the composition of the extracellular matrix and the presence of secreted matricellular proteins all contribute to essential adhesion signaling during lactogenesis. In vitro and in vivo studies, including the results from genetically engineered mice, have shed light on the regulation of these processes at the cell and tissue level and have led to increased understanding of the essential signaling components that are regulated in temporal and cell specific manner during lactogenesis. Recent studies suggest that a secreted matricellular protein, CTGF/CCN2, may play a role in lactogenic differentiation through binding to β1 integrin complexes, enhancing the production of extracellular matrix components and contributions to cell adhesion signaling.
AB - The mammary gland undergoes hormonally controlled cycles of pubertal maturation, pregnancy, lactation, and involution, and these processes rely on complex signaling mechanisms, many of which are controlled by cell-cell and cell-matrix adhesion. The adhesion of epithelial cells to the extracellular matrix initiates signaling mechanisms that have an impact on cell proliferation, survival, and differentiation throughout lactation. The control of integrin expression on the mammary epithelial cells, the composition of the extracellular matrix and the presence of secreted matricellular proteins all contribute to essential adhesion signaling during lactogenesis. In vitro and in vivo studies, including the results from genetically engineered mice, have shed light on the regulation of these processes at the cell and tissue level and have led to increased understanding of the essential signaling components that are regulated in temporal and cell specific manner during lactogenesis. Recent studies suggest that a secreted matricellular protein, CTGF/CCN2, may play a role in lactogenic differentiation through binding to β1 integrin complexes, enhancing the production of extracellular matrix components and contributions to cell adhesion signaling.
KW - Adhesion
KW - CCN2
KW - CTGF
KW - Connective tissue growth factor
KW - Integrin
KW - Lactogenesis
KW - Mammary gland
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=77958475757&partnerID=8YFLogxK
U2 - 10.1007/s12079-010-0099-6
DO - 10.1007/s12079-010-0099-6
M3 - Review article
AN - SCOPUS:77958475757
SN - 1873-9601
VL - 4
SP - 131
EP - 139
JO - Journal of Cell Communication and Signaling
JF - Journal of Cell Communication and Signaling
IS - 3
ER -