The contribution of adhesion signaling to lactogenesis

Bethanie Morrison, Mary Lou Cutler

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


The mammary gland undergoes hormonally controlled cycles of pubertal maturation, pregnancy, lactation, and involution, and these processes rely on complex signaling mechanisms, many of which are controlled by cell-cell and cell-matrix adhesion. The adhesion of epithelial cells to the extracellular matrix initiates signaling mechanisms that have an impact on cell proliferation, survival, and differentiation throughout lactation. The control of integrin expression on the mammary epithelial cells, the composition of the extracellular matrix and the presence of secreted matricellular proteins all contribute to essential adhesion signaling during lactogenesis. In vitro and in vivo studies, including the results from genetically engineered mice, have shed light on the regulation of these processes at the cell and tissue level and have led to increased understanding of the essential signaling components that are regulated in temporal and cell specific manner during lactogenesis. Recent studies suggest that a secreted matricellular protein, CTGF/CCN2, may play a role in lactogenic differentiation through binding to β1 integrin complexes, enhancing the production of extracellular matrix components and contributions to cell adhesion signaling.

Original languageEnglish
Pages (from-to)131-139
Number of pages9
JournalJournal of Cell Communication and Signaling
Issue number3
StatePublished - Oct 2010
Externally publishedYes


  • Adhesion
  • CCN2
  • CTGF
  • Connective tissue growth factor
  • Integrin
  • Lactogenesis
  • Mammary gland
  • Signal transduction


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