@inbook{2df173a06a1f4fc7a115db35be6b8e90,
title = "The Controlled Human Infection Model for Enterotoxigenic Escherichia coli",
abstract = "The controlled human infection model (CHIM) for enterotoxigenic Escherichia coli (ETEC) has been instrumental in defining ETEC as a causative agent of acute watery diarrhea, providing insights into disease pathogenesis and resistance to illness, and enabling preliminary efficacy evaluations for numerous products including vaccines, immunoprophylactics, and drugs. Over a dozen strains have been evaluated to date, with a spectrum of clinical signs and symptoms that appear to replicate the clinical illness seen with naturally occurring ETEC. Recent advancements in the ETEC CHIM have enhanced the characterization of clinical, immunological, and microbiological outcomes. It is anticipated that omics-based technologies applied to ETEC CHIMs will continue to broaden our understanding of host–pathogen interactions and facilitate the development of primary and secondary prevention strategies.",
keywords = "CHIM, Clinical trial, Controlled human infection model, Diarrhea, Enterotoxigenic Escherichia coli; ETEC, Experimental infection, Travelers{\textquoteright} diarrhea, Vaccine",
author = "Porter, {Chad K.} and Talaat, {Kawsar R.} and Isidean, {Sandra D.} and Alwine Kardinaal and Subhra Chakraborty and Guti{\'e}rrez, {Ramiro L.} and Sack, {David A.} and Bourgeois, {A. Louis}",
note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive license to Springer Nature Switzerland AG 2021.",
year = "2024",
doi = "10.1007/82_2021_242",
language = "English",
series = "Current Topics in Microbiology and Immunology",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "189--228",
booktitle = "Current Topics in Microbiology and Immunology",
}