TY - JOUR
T1 - The dynamics of acute inflammation
AU - Kumar, Rukmini
AU - Clermont, Gilles
AU - Vodovotz, Yoram
AU - Chow, Carson C.
N1 - Funding Information:
This work was funded in part by NIGMS Grant R01-GM-67240 and the A.P. Sloan Foundation.
PY - 2004/9/21
Y1 - 2004/9/21
N2 - When the body is infected, it mounts an acute inflammatory response to rid itself of the pathogens and restore health. Uncontrolled acute inflammation due to infection is defined clinically as sepsis and can culminate in organ failure and death. We consider a three-dimensional ordinary differential equation model of inflammation consisting of a pathogen, and two inflammatory mediators. The model reproduces the healthy outcome and diverse negative outcomes, depending on initial conditions and parameters. We analyze the various bifurcations between the different outcomes when key parameters are changed and suggest various therapeutic strategies. We suggest that the clinical condition of sepsis can arise from several distinct physiological states, each of which requires a different treatment approach.
AB - When the body is infected, it mounts an acute inflammatory response to rid itself of the pathogens and restore health. Uncontrolled acute inflammation due to infection is defined clinically as sepsis and can culminate in organ failure and death. We consider a three-dimensional ordinary differential equation model of inflammation consisting of a pathogen, and two inflammatory mediators. The model reproduces the healthy outcome and diverse negative outcomes, depending on initial conditions and parameters. We analyze the various bifurcations between the different outcomes when key parameters are changed and suggest various therapeutic strategies. We suggest that the clinical condition of sepsis can arise from several distinct physiological states, each of which requires a different treatment approach.
KW - Ordinary differential equation (ODE) models
KW - Phase-space and bifurcation analysis
KW - Sepsis
KW - Systemic inflammation
UR - http://www.scopus.com/inward/record.url?scp=4043154901&partnerID=8YFLogxK
U2 - 10.1016/j.jtbi.2004.04.044
DO - 10.1016/j.jtbi.2004.04.044
M3 - Article
C2 - 15321710
AN - SCOPUS:4043154901
SN - 0022-5193
VL - 230
SP - 145
EP - 155
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
IS - 2
ER -