The effect of propranolol on catecholamine clearance

Michael G. Ziegler*, Bart Chernow, Lee C. Woodson, Joseph Coyle, David Cruess, C. Raymond Lake

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Normal subjects given propranolol increased their plasma t 1 2 for infused isoproterenol from 2.68 to 6.25 minutes. Propranolol increased plasma norepinephrine (NE) levels only slightly. Propranolol increased the t 1 2 of isoproterenol but not that of NE in men with autonomic nervous system degeneration. This suggests that propranolol acts on nonneuronal uptake-2 processes, rather than on uptake-1 mechanisms. α-Blockers slow uptake-1 and β-blockers slow uptake-2 processes. When 27 subjects exercised, those who attained the highest plasma levels of the α- and β-receptor agonist NE also had the briefest apparent t 1 2 for NE. Adrenergic receptor blocking drugs slow catecholamine clearance. NE may stimulate its own clearance.

Original languageEnglish
Pages (from-to)116-119
Number of pages4
JournalClinical Pharmacology and Therapeutics
Issue number1
StatePublished - Jul 1986
Externally publishedYes


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