The effect of rotavirus immunization on rotavirus gastroenteritis hospitalization rates in military dependents

Matthew D. Eberly; Greg H. Gorman; Matilda B. Eide; Cara H. Olsen; Michael Rajnik

doi:10.1016/j.vaccine.2010.11.041

The effect of rotavirus immunization on rotavirus gastroenteritis hospitalization rates in military dependents

Matthew D. Eberly^*, Greg H. Gorman, Matilda B. Eide, Cara H. Olsen, Michael Rajnik

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We conducted a retrospective review of all U.S. military dependents less than 5 years old hospitalized with rotavirus-associated gastroenteritis from July 2003 to June 2009. The two post-vaccine seasons showed a significant reduction of 62.4% (95% CI, 58.6-65.8, P< 0.001) in rotavirus gastroenteritis hospitalization rate compared to the three pre-vaccine seasons. Infants less than 12 months old showed the greatest reduction in incidence at 75.3%. A substantial decrease was also seen in unvaccinated children as well. Vaccine efficacy against hospitalization was 86.0% (95% CI, 77.7-91.3) after just a single dose. The overwhelming majority of children hospitalized for rotavirus since the introduction of the vaccine (ranging from 91.8 to 100% per season) had not received any of the rotavirus vaccine series.

Original language	English
Pages (from-to)	650-659
Number of pages	10
Journal	Vaccine
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/j.vaccine.2010.11.041
State	Published - 17 Jan 2011
Externally published	Yes

Keywords

Hospitalization
Rotavirus gastroenteritis
Rotavirus vaccine
Vaccine efficacy

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10.1016/j.vaccine.2010.11.041

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title = "The effect of rotavirus immunization on rotavirus gastroenteritis hospitalization rates in military dependents",

abstract = "We conducted a retrospective review of all U.S. military dependents less than 5 years old hospitalized with rotavirus-associated gastroenteritis from July 2003 to June 2009. The two post-vaccine seasons showed a significant reduction of 62.4% (95% CI, 58.6-65.8, P< 0.001) in rotavirus gastroenteritis hospitalization rate compared to the three pre-vaccine seasons. Infants less than 12 months old showed the greatest reduction in incidence at 75.3%. A substantial decrease was also seen in unvaccinated children as well. Vaccine efficacy against hospitalization was 86.0% (95% CI, 77.7-91.3) after just a single dose. The overwhelming majority of children hospitalized for rotavirus since the introduction of the vaccine (ranging from 91.8 to 100% per season) had not received any of the rotavirus vaccine series.",

keywords = "Hospitalization, Rotavirus gastroenteritis, Rotavirus vaccine, Vaccine efficacy",

author = "Eberly, {Matthew D.} and Gorman, {Greg H.} and Eide, {Matilda B.} and Olsen, {Cara H.} and Michael Rajnik",

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AU - Eberly, Matthew D.

AU - Gorman, Greg H.

AU - Eide, Matilda B.

AU - Olsen, Cara H.

AU - Rajnik, Michael

PY - 2011/1/17

Y1 - 2011/1/17

N2 - We conducted a retrospective review of all U.S. military dependents less than 5 years old hospitalized with rotavirus-associated gastroenteritis from July 2003 to June 2009. The two post-vaccine seasons showed a significant reduction of 62.4% (95% CI, 58.6-65.8, P< 0.001) in rotavirus gastroenteritis hospitalization rate compared to the three pre-vaccine seasons. Infants less than 12 months old showed the greatest reduction in incidence at 75.3%. A substantial decrease was also seen in unvaccinated children as well. Vaccine efficacy against hospitalization was 86.0% (95% CI, 77.7-91.3) after just a single dose. The overwhelming majority of children hospitalized for rotavirus since the introduction of the vaccine (ranging from 91.8 to 100% per season) had not received any of the rotavirus vaccine series.

AB - We conducted a retrospective review of all U.S. military dependents less than 5 years old hospitalized with rotavirus-associated gastroenteritis from July 2003 to June 2009. The two post-vaccine seasons showed a significant reduction of 62.4% (95% CI, 58.6-65.8, P< 0.001) in rotavirus gastroenteritis hospitalization rate compared to the three pre-vaccine seasons. Infants less than 12 months old showed the greatest reduction in incidence at 75.3%. A substantial decrease was also seen in unvaccinated children as well. Vaccine efficacy against hospitalization was 86.0% (95% CI, 77.7-91.3) after just a single dose. The overwhelming majority of children hospitalized for rotavirus since the introduction of the vaccine (ranging from 91.8 to 100% per season) had not received any of the rotavirus vaccine series.

KW - Hospitalization

KW - Rotavirus gastroenteritis

KW - Rotavirus vaccine

KW - Vaccine efficacy

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The effect of rotavirus immunization on rotavirus gastroenteritis hospitalization rates in military dependents

Abstract

Keywords

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