The effect of source animal age upon the in vivo remodeling characteristics of an extracellular matrix scaffold

Brian M. Sicari, Scott A. Johnson, Bernard F. Siu, Peter M. Crapo, Kerry A. Daly, Hongbin Jiang, Christopher J. Medberry, Stephen Tottey, Neill J. Turner, Stephen F. Badylak*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

Biologic scaffolds composed of mammalian extracellular matrix (ECM) are routinely used for the repair and reconstruction of injured or missing tissues in a variety of pre-clinical and clinical applications. However, the structural and functional outcomes have varied considerably. An important variable of xenogeneic biologic scaffolds is the age of the animal from which the ECM is derived. The present study compared the . in vivo host response and remodeling outcomes of biologic scaffolds composed of small intestinal submucosa (SIS)-ECM harvested from pigs that differed only in age. Results showed that there are distinct differences in the remodeling characteristics as a consequence of source animal age. Scaffolds derived from younger animals were associated with a more constructive, site appropriate, tissue remodeling response than scaffolds derived from older animals. Furthermore, the constructive remodeling response was associated with a dominant M2 macrophage response.

Original languageEnglish
Pages (from-to)5524-5533
Number of pages10
JournalBiomaterials
Volume33
Issue number22
DOIs
StatePublished - Aug 2012
Externally publishedYes

Keywords

  • Age/ageing
  • ECM (extracellular matrix)
  • Immune response
  • Macrophage
  • Mechanical properties
  • Scaffold

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