The extracellular matrix as a scaffold for tissue reconstruction

Stephen F. Badylak*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

705 Scopus citations


The extracellular matrix (ECM) consists of a complex mixture of structural and functional proteins and serves an important role in tissue and organ morphogenesis, maintenance of cell and tissue structure and function, and in the host response to injury. Xenogeneic and allogeneic ECM has been used as a bioscaffold for the reconstruction of many different tissue types in both pre-clinical and human clinical studies. Common features of ECM-associated tissue remodeling include extensive angiogenesis, recruitment of circulating progenitor cells, rapid scaffold degradation and constructive remodeling of damaged or missing tissues. The ECM-induced remodeling response is a distinctly different phenomenon from that of scar tissue formation.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalSeminars in Cell and Developmental Biology
Issue number5
StatePublished - 2002
Externally publishedYes


  • Bioscaffolds
  • Extracellular matrix
  • Small intestinal submucosa (SIS)
  • Tissue engineering
  • Urinary bladder submucosa (UBS)


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