TY - JOUR
T1 - The Impact of Optic Nerve Movement on Intracranial Radiation Treatment
AU - Qing, Kun
AU - Nie, Ke
AU - Liu, Bo
AU - Feng, Xue
AU - Stone, James R.
AU - Cui, Taoran
AU - Zhang, Yin
AU - Zhu, Jiahua
AU - Chen, Quan
AU - Wang, Xiao
AU - Zhao, Li
AU - Parikh, Shreel
AU - Mugler, John P.
AU - Kim, Sung
AU - Weiner, Joseph
AU - Yue, Ning
AU - Chundury, Anupama
N1 - Publisher Copyright:
Copyright © 2022 Qing, Nie, Liu, Feng, Stone, Cui, Zhang, Zhu, Chen, Wang, Zhao, Parikh, Mugler, Kim, Weiner, Yue and Chundury.
PY - 2022/2/24
Y1 - 2022/2/24
N2 - Purpose: In radiotherapy, high radiation exposure to optic nerve (ON) can cause optic neuropathy or vision loss. In this study, we evaluated the pattern and extent of the ON movement using MRI, and investigated the potential dosimetric effect of this movement on radiotherapy. Methods: MRI was performed in multiple planes in 5 human subjects without optic pathway abnormalities to determine optic nerve motion in different scenarios. The subjects were requested to gaze toward five directions during MRI acquisitions, including neutral (straight forward), left/right (horizontal movement), and up/down (vertical movement). Subsequently, the measured displacement was applied to patients with peri-optic tumors to evaluate the potential dosimetric effect of this motion. Results: The motion of ON followed a nearly conical shape. By average, the anterior end of ONs moved with 10.8 ± 2.2 mm horizontally and 9.3 ± 0.8 mm vertically, while posterior end has negligible displacement. For patients who underwent stereotactic radiotherapy to a peri-optic tumors, the movement of ON in this measured range introduced non-negligible dosimetric effect. Conclusion: The range of motion of the anterior portions of the optic nerves is on the order of centimeters, which may need to be considered with extra attention during radiation therapy in treating peri-optic lesions.
AB - Purpose: In radiotherapy, high radiation exposure to optic nerve (ON) can cause optic neuropathy or vision loss. In this study, we evaluated the pattern and extent of the ON movement using MRI, and investigated the potential dosimetric effect of this movement on radiotherapy. Methods: MRI was performed in multiple planes in 5 human subjects without optic pathway abnormalities to determine optic nerve motion in different scenarios. The subjects were requested to gaze toward five directions during MRI acquisitions, including neutral (straight forward), left/right (horizontal movement), and up/down (vertical movement). Subsequently, the measured displacement was applied to patients with peri-optic tumors to evaluate the potential dosimetric effect of this motion. Results: The motion of ON followed a nearly conical shape. By average, the anterior end of ONs moved with 10.8 ± 2.2 mm horizontally and 9.3 ± 0.8 mm vertically, while posterior end has negligible displacement. For patients who underwent stereotactic radiotherapy to a peri-optic tumors, the movement of ON in this measured range introduced non-negligible dosimetric effect. Conclusion: The range of motion of the anterior portions of the optic nerves is on the order of centimeters, which may need to be considered with extra attention during radiation therapy in treating peri-optic lesions.
KW - MRI
KW - optical nerve
KW - radiation therapy
KW - radiation-induced optic neuropathy
KW - stereotactic radiodiotherapy
UR - http://www.scopus.com/inward/record.url?scp=85126223638&partnerID=8YFLogxK
U2 - 10.3389/fonc.2022.803329
DO - 10.3389/fonc.2022.803329
M3 - Article
AN - SCOPUS:85126223638
SN - 2234-943X
VL - 12
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 803329
ER -