The multifaceted roles of nitric oxide in cancer

D. A. Wink; Y. Vodovotz; J. Laval; F. Laval; M. W. Dewhirst; J. B. Mitchell

doi:10.1093/carcin/19.5.711

The multifaceted roles of nitric oxide in cancer

D. A. Wink^*, Y. Vodovotz, J. Laval, F. Laval, M. W. Dewhirst, J. B. Mitchell

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

650 Scopus citations

Abstract

The roles of nitric oxide (NO) in numerous disease states have generated considerable discussion over the past several years. NO has been labeled as the causative agent in different pathophysiological mechanisms, yet appears to protect against various chemical species such as those generated under oxidative stress. Similarly, NO appears to exert a dichotomy of effects within the multistage model of cancer. Chronic inflammation can lead to the production of chemical intermediates, among them NO, which in turn can mediate damage to DNA. Yet, NO also appears to be critical for the tumoricidal activity of the immune system. Furthermore, NO can also have a multitude of effects on other aspects of tumor biology, including angiogenesis and metastasis. This report will discuss how the chemistry of NO may impact the initiation and progression stages of cancer.

Original language	English
Pages (from-to)	711-721
Number of pages	11
Journal	Carcinogenesis
Volume	19
Issue number	5
DOIs	https://doi.org/10.1093/carcin/19.5.711
State	Published - 1998
Externally published	Yes

Access to Document

10.1093/carcin/19.5.711

Cite this

@article{fb92ca7f31d44e599fc37b90387a438f,

title = "The multifaceted roles of nitric oxide in cancer",

abstract = "The roles of nitric oxide (NO) in numerous disease states have generated considerable discussion over the past several years. NO has been labeled as the causative agent in different pathophysiological mechanisms, yet appears to protect against various chemical species such as those generated under oxidative stress. Similarly, NO appears to exert a dichotomy of effects within the multistage model of cancer. Chronic inflammation can lead to the production of chemical intermediates, among them NO, which in turn can mediate damage to DNA. Yet, NO also appears to be critical for the tumoricidal activity of the immune system. Furthermore, NO can also have a multitude of effects on other aspects of tumor biology, including angiogenesis and metastasis. This report will discuss how the chemistry of NO may impact the initiation and progression stages of cancer.",

author = "Wink, {D. A.} and Y. Vodovotz and J. Laval and F. Laval and Dewhirst, {M. W.} and Mitchell, {J. B.}",

year = "1998",

doi = "10.1093/carcin/19.5.711",

language = "English",

volume = "19",

pages = "711--721",

journal = "Carcinogenesis",

issn = "0143-3334",

number = "5",

}

TY - JOUR

T1 - The multifaceted roles of nitric oxide in cancer

AU - Wink, D. A.

AU - Vodovotz, Y.

AU - Laval, J.

AU - Laval, F.

AU - Dewhirst, M. W.

AU - Mitchell, J. B.

PY - 1998

Y1 - 1998

N2 - The roles of nitric oxide (NO) in numerous disease states have generated considerable discussion over the past several years. NO has been labeled as the causative agent in different pathophysiological mechanisms, yet appears to protect against various chemical species such as those generated under oxidative stress. Similarly, NO appears to exert a dichotomy of effects within the multistage model of cancer. Chronic inflammation can lead to the production of chemical intermediates, among them NO, which in turn can mediate damage to DNA. Yet, NO also appears to be critical for the tumoricidal activity of the immune system. Furthermore, NO can also have a multitude of effects on other aspects of tumor biology, including angiogenesis and metastasis. This report will discuss how the chemistry of NO may impact the initiation and progression stages of cancer.

AB - The roles of nitric oxide (NO) in numerous disease states have generated considerable discussion over the past several years. NO has been labeled as the causative agent in different pathophysiological mechanisms, yet appears to protect against various chemical species such as those generated under oxidative stress. Similarly, NO appears to exert a dichotomy of effects within the multistage model of cancer. Chronic inflammation can lead to the production of chemical intermediates, among them NO, which in turn can mediate damage to DNA. Yet, NO also appears to be critical for the tumoricidal activity of the immune system. Furthermore, NO can also have a multitude of effects on other aspects of tumor biology, including angiogenesis and metastasis. This report will discuss how the chemistry of NO may impact the initiation and progression stages of cancer.

UR - http://www.scopus.com/inward/record.url?scp=0031845632&partnerID=8YFLogxK

U2 - 10.1093/carcin/19.5.711

DO - 10.1093/carcin/19.5.711

M3 - Review article

C2 - 9635855

AN - SCOPUS:0031845632

SN - 0143-3334

VL - 19

SP - 711

EP - 721

JO - Carcinogenesis

JF - Carcinogenesis

IS - 5

ER -

The multifaceted roles of nitric oxide in cancer

Abstract

Access to Document

Fingerprint

Cite this