The natural history of symptomatic arteriovenous malformations of the brain: A 24-year follow-up assessment

S. L. Ondra*, H. Troupp, E. D. George, K. Schwab

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

900 Scopus citations

Abstract

The authors have updated a series of 166 prospectively followed unoperated symptomatic patients with arteriovenous malformation (AVM's) of the brain. Follow-up data were obtained for 160 (96%) of the original population, with a mean follow-up period of 23.7 years. The rate of major rebleeding was 4.0% per year, and the mortality rate was 1.0% per year. At follow-up review, 23% of the series were dead from AVM hemorrhage. The combined rate of major morbidity and mortality was 2.7% per year. These annual rates remained essentially constant over the entire period of the study. There was no difference in the incidence of rebleeding or death regardless of presentation with or without evidence of hemorrhage. The mean interval between initial presentation and subsequent hemorrhage was 7.7 years.

Original languageEnglish
Pages (from-to)387-391
Number of pages5
JournalJournal of Neurosurgery
Volume73
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • arteriovenous malformation
  • natural history
  • rebleeding

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