The potential roles for adipose tissue in peripheral nerve regeneration

Frances M. Walocko, Roger K. Khouri, Melanie G. Urbanchek, Benjamin Levi, Paul S. Cederna*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Introduction This review summarizes current understanding about the role of adipose-derived tissues in peripheral nerve regeneration and discusses potential advances that would translate this approach into the clinic. Methods We searched PubMed for in vivo, experimental studies on the regenerative effects of adipose-derived tissues on peripheral nerve injuries. We summarized the methods and results for the 42 experiments. Results Adipose-derived tissues enhanced peripheral nerve regeneration in 86% of the experiments. Ninety-five percent evaluated purified, cultured, or differentiated adipose tissue. These approaches have regulatory and scaling burdens, restricting clinical usage. Only one experiment tested the ability of adipose tissue to enhance nerve regeneration in conjunction with nerve autografts, the clinical gold standard. Conclusion Scientific studies illustrate that adipose-derived tissues enhance regeneration of peripheral nerves. Before this approach achieves clinical acceptance, fat processing must become automated and regulatory approval achieved. Animal studies using whole fat grafts are greatly needed for clinical translation.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
Issue number1
StatePublished - 1 Jan 2016
Externally publishedYes


Dive into the research topics of 'The potential roles for adipose tissue in peripheral nerve regeneration'. Together they form a unique fingerprint.

Cite this