The revised neurobehavioral severity scale (NSS-R) for rodents

Angela M. Yarnell, Erin S. Barry, Andrea Mountney, Deborah Shear, Frank Tortella, Neil E. Grunberg

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Motor and sensory deficits are common following traumatic brain injury (TBI). Although rodent models provide valuable insight into the biological and functional outcomes of TBI, the success of translational research is critically dependent upon proper selection of sensitive, reliable, and reproducible assessments. Published literature includes various observational scales designed to evaluate post-injury functionality; however, the heterogeneity in TBI location, severity, and symptomology can complicate behavioral assessments. The importance of choosing behavioral outcomes that can be reliably and objectively quantified in an efficient manner is becoming increasingly important. The Revised Neurobehavioral Severity Scale (NSS-R) is a continuous series of specific, sensitive, and standardized observational tests that evaluate balance, motor coordination, and sensorimotor reflexes in rodents. The tasks follow a specific order designed to minimize interference: balance, landing, tail raise, dragging, righting reflex, ear reflex, eye reflex, sound reflex, tail pinch, and hindpaw pinch. The NSS-R has proven to be a reliable method differentiating brain-injured rodents from non-brain-injured rodents across many brain injury models.

Original languageEnglish
Pages (from-to)9.52.1-9.52.16
JournalCurrent Protocols in Neuroscience
Volume2016
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • NSS-R
  • Neurobehavioral severity scale revised
  • Rat
  • Traumatic brain injury

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