The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression

Nelson L. Michael*, Leslie G. Louie, Amy L. Rohrbaugh, Kathleen A. Schultz, Debora E. Dayhoff, Carol E. Wang, Haynes W. Sheppard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

225 Scopus citations

Abstract

Entry of human immunodeficiency virus type 1 (HIV-1) into target cells requires both CD4(ref. 1, 2) and one of a growing number of G-protein- coupled seven-transmembrane receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 or CXCR4, although other receptors, including CCR2B and CCR3, function as minor co-receptors. CCR3 appears critical in central nervous system infection. A 32-base pair inactivating deletion in CCR5 (Δ32) common to Northern European populations has been associated with reduced, but not absolute HIV-1 transmission risk and delayed disease progression. A more commonly distributed transition causing a valine to isoleucine switch in transmembrane domain I of CCR2B (64I) with unknown functional consequences was recently shown to delay disease progression but not reduce infection risk. Although we confirm the lack of association of CCR2B 64I with transmission, we cannot confirm the association with delayed progression. Although subjects with CCR5 Δ32 defects had significantly reduced median viral load at study entry, providing a plausible explanation for the association with delayed progression, this association was not seen with CCR2B 64I. Further studies are needed to define the role of CCR2B 64I in HIV pathogenesis.

Original languageEnglish
Pages (from-to)1160-1162
Number of pages3
JournalNature Medicine
Volume3
Issue number10
DOIs
StatePublished - Oct 1997
Externally publishedYes

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