TY - JOUR
T1 - The Role of Genomics and Proteomics
T2 - Technologies in Studying Non-alcoholic Fatty Liver Disease
AU - Baranova, Ancha
AU - Liotta, Lance
AU - Petricoin, Emanuel
AU - Younossi, Zobair M.
PY - 2007/2
Y1 - 2007/2
N2 - Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are examples of complex diseases accompanied by changes in the expression of thousands of genes and a plethora of proteins encoded by these genes. Before the era of high-throughput analysis, typical translational research initiatives, aimed at defining the molecular targets for complex diseases, were performed on gene-by-gene basis. Innovative technologies, such as expression microarrays, mass spectromety, and reverse proteomics, now allow investigators to reveal complex patterns of the expression of biologically active molecules. For this reason, high-throughput approaches may be well suited for studies designed to untangle the molecular basis of the chronic liver diseases such as NAFLD.
AB - Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are examples of complex diseases accompanied by changes in the expression of thousands of genes and a plethora of proteins encoded by these genes. Before the era of high-throughput analysis, typical translational research initiatives, aimed at defining the molecular targets for complex diseases, were performed on gene-by-gene basis. Innovative technologies, such as expression microarrays, mass spectromety, and reverse proteomics, now allow investigators to reveal complex patterns of the expression of biologically active molecules. For this reason, high-throughput approaches may be well suited for studies designed to untangle the molecular basis of the chronic liver diseases such as NAFLD.
UR - http://www.scopus.com/inward/record.url?scp=34249706743&partnerID=8YFLogxK
U2 - 10.1016/j.cld.2007.02.003
DO - 10.1016/j.cld.2007.02.003
M3 - Review article
C2 - 17544980
AN - SCOPUS:34249706743
SN - 1089-3261
VL - 11
SP - 209
EP - 220
JO - Clinics in Liver Disease
JF - Clinics in Liver Disease
IS - 1
ER -