The role of nitric oxide in apoptosis

Jianrong Li, Timothy R. Billiar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Nitric oxide (NO) has been shown to play important roles in modulating cell viability. Both proapoptotic and antiapoptotic functions of NO have been reported. This article discusses our current understanding on the mechanisms responsible for the dual actions of NO in regulating apoptosis and propose that one common mechanism for NO-mediated inhibition of apoptosis is the inhibition of caspases via nitrosylation. Copyright (C) 2000 by W.B. Saunders Company.

Original languageEnglish
Pages (from-to)46-50
Number of pages5
JournalSeminars in Perinatology
Issue number1
StatePublished - 2000
Externally publishedYes


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