TY - JOUR
T1 - The role of nitric oxide in apoptosis
AU - Li, Jianrong
AU - Billiar, Timothy R.
N1 - Funding Information:
From the Department of Surgeu, University of Pittsburgh School of Medicine, Pittsburgh, PA. The research was supported by National Institutes of Health (NIH) grants" GM-441 O0 and GM-3 7753. Li is supported by a postdoctoral fellowship from the National Research Service Award GM19866. Address reprint requests to Timothy R. BiUiar, MD, Watson Professor of Surgery, Rm 676-Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15261; e-mail: [email protected] Copyright 9 2000 by W.B. Saunders Company 0146-0005/00/2401-0012510. 00/0
PY - 2000
Y1 - 2000
N2 - Nitric oxide (NO) has been shown to play important roles in modulating cell viability. Both proapoptotic and antiapoptotic functions of NO have been reported. This article discusses our current understanding on the mechanisms responsible for the dual actions of NO in regulating apoptosis and propose that one common mechanism for NO-mediated inhibition of apoptosis is the inhibition of caspases via nitrosylation. Copyright (C) 2000 by W.B. Saunders Company.
AB - Nitric oxide (NO) has been shown to play important roles in modulating cell viability. Both proapoptotic and antiapoptotic functions of NO have been reported. This article discusses our current understanding on the mechanisms responsible for the dual actions of NO in regulating apoptosis and propose that one common mechanism for NO-mediated inhibition of apoptosis is the inhibition of caspases via nitrosylation. Copyright (C) 2000 by W.B. Saunders Company.
UR - http://www.scopus.com/inward/record.url?scp=0034054955&partnerID=8YFLogxK
U2 - 10.1016/S0146-0005(00)80055-5
DO - 10.1016/S0146-0005(00)80055-5
M3 - Article
C2 - 10709859
AN - SCOPUS:0034054955
SN - 0146-0005
VL - 24
SP - 46
EP - 50
JO - Seminars in Perinatology
JF - Seminars in Perinatology
IS - 1
ER -