The role of the histoblood ABO group in cancer

Seth K. Rummel, Rachel E. Ellsworth*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Since the first link between blood type and cancer was described in 1953, numerous studies have sought to determine whether the histoblood ABO group is associated with tumorigenesis. In 2009, the first significant association between a SNP located within the ABO glycosyltransferase gene and increased risk of pancreatic cancer was reported. Here, we describe the history and possible functions of the histoblood ABO group and then provide evidence for a role of blood group antigens in the most common cancer types worldwide using both blood type and SNP data. We also explore whether confusion regarding the role of blood type in cancer risk may be attributable to heterogeneity within tumor types.

Original languageEnglish
Article numberFSO107
JournalFuture Science OA
Volume2
Issue number2
DOIs
StatePublished - Jun 2016
Externally publishedYes

Keywords

  • cancer
  • histoblood ABO group
  • rs505922

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