The Role of the Host Immune Response in Tissue Engineering and Regenerative Medicine

Bryan N. Brown*, Stephen F. Badylak

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

12 Scopus citations

Abstract

Tissue engineering and regenerative medicine-based approaches commonly employ a combination of scaffolds, cells, and bioactive molecules. Regardless of the approach used for each clinical application, the objective is the same; specifically, the restoration of structure and function. Similarly, regardless of which strategy is selected, the response of the host to the implanted construct will dictate the success or failure of the eventual outcome. It is unlikely that the host response can be avoided and, therefore, designs which incorporate an in-depth understanding of the host immune response together with other requisite criteria will likely meet with improved success and downstream functionality. The present chapter briefly reviews the default mechanisms of wound healing, the foreign body response to non-degradable permanent implants, and the host response to various strategies employed within tissue-engineered constructs. Particular emphasis is placed upon newly defined paradigms surrounding the host macrophage response.

Original languageEnglish
Title of host publicationPrinciples of Tissue Engineering
Subtitle of host publicationFourth Edition
PublisherElsevier Inc.
Pages497-509
Number of pages13
ISBN (Print)9780123983589
DOIs
StatePublished - Nov 2013
Externally publishedYes

Keywords

  • Biomaterials
  • Foreign body giant cell
  • Foreign body reaction
  • Host response
  • Implant
  • Macrophage
  • Regenerative medicine
  • Scaffold
  • T cell
  • Tissue engineering
  • Wound healing

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