The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity

Simon D. Pollett; Stephanie A. Richard; Anthony C. Fries; Mark P. Simons; Katrin Mende; Tahaniyat Lalani; Tida Lee; Sharon Chi; Rupal Mody; Cristian Madar; Anuradha Ganesan; Derek T. Larson; Christopher J. Colombo; Rhonda Colombo; Emily C. Samuels; Christopher C. Broder; Eric D. Laing; Darci R. Smith; David Tribble; Brian K. Agan; Timothy H. Burgess

doi:10.1093/cid/ciab543

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity

Simon D. Pollett^*
, Stephanie A. Richard
, Anthony C. Fries
, Mark P. Simons
, Katrin Mende
, Tahaniyat Lalani
, Tida Lee
, Sharon Chi
, Rupal Mody
, Cristian Madar
, Anuradha Ganesan
, Derek T. Larson
, Christopher J. Colombo
, Rhonda Colombo
, Emily C. Samuels
, Christopher C. Broder
, Eric D. Laing
, Darci R. Smith
, David Tribble
, Brian K. Agan

Timothy H. Burgess

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Little is known about severe acute respiratory syndrome coronavirus 2 "vaccine-breakthrough"infections (VBIs). Here we characterize 24 VBIs in predominantly young healthy persons. While none required hospitalization, a proportion endorsed severe symptoms and shed live virus as high as 4.13 × 103 plaque-forming units/mL. Infecting genotypes included both variant-of-concern (VOC) and non-VOC strains.

Original language	English
Pages (from-to)	897-900
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	74
Issue number	5
DOIs	https://doi.org/10.1093/cid/ciab543
State	Published - 1 Mar 2022

Keywords

SARS-CoV-2
live virus
patient-reported outcomes
symptoms
vaccine breakthrough

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10.1093/cid/ciab543

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Pollett, S. D., Richard, S. A., Fries, A. C., Simons, M. P., Mende, K., Lalani, T., Lee, T., Chi, S., Mody, R., Madar, C., Ganesan, A., Larson, D. T., Colombo, C. J., Colombo, R., Samuels, E. C., Broder, C. C., Laing, E. D., Smith, D. R., Tribble, D., ... Burgess, T. H. (2022). The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity. Clinical Infectious Diseases, 74(5), 897-900. https://doi.org/10.1093/cid/ciab543

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title = "The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity",

abstract = "Little is known about severe acute respiratory syndrome coronavirus 2 {"}vaccine-breakthrough{"}infections (VBIs). Here we characterize 24 VBIs in predominantly young healthy persons. While none required hospitalization, a proportion endorsed severe symptoms and shed live virus as high as 4.13 × 103 plaque-forming units/mL. Infecting genotypes included both variant-of-concern (VOC) and non-VOC strains.",

keywords = "SARS-CoV-2, live virus, patient-reported outcomes, symptoms, vaccine breakthrough",

author = "Pollett, \{Simon D.\} and Richard, \{Stephanie A.\} and Fries, \{Anthony C.\} and Simons, \{Mark P.\} and Katrin Mende and Tahaniyat Lalani and Tida Lee and Sharon Chi and Rupal Mody and Cristian Madar and Anuradha Ganesan and Larson, \{Derek T.\} and Colombo, \{Christopher J.\} and Rhonda Colombo and Samuels, \{Emily C.\} and Broder, \{Christopher C.\} and Laing, \{Eric D.\} and Smith, \{Darci R.\} and David Tribble and Agan, \{Brian K.\} and Burgess, \{Timothy H.\}",

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doi = "10.1093/cid/ciab543",

language = "English",

volume = "74",

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Pollett, SD , Richard, SA, Fries, AC, Simons, MP , Mende, K , Lalani, T, Lee, T, Chi, S, Mody, R, Madar, C, Ganesan, A, Larson, DT, Colombo, CJ , Colombo, R, Samuels, EC, Broder, CC , Laing, ED, Smith, DR, Tribble, D , Agan, BK & Burgess, TH 2022, 'The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity', Clinical Infectious Diseases, vol. 74, no. 5, pp. 897-900. https://doi.org/10.1093/cid/ciab543

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity. / Pollett, Simon D.; Richard, Stephanie A.; Fries, Anthony C. et al.
In: Clinical Infectious Diseases, Vol. 74, No. 5, 01.03.2022, p. 897-900.

Research output: Contribution to journal › Article › peer-review

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The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity

Abstract

Keywords

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