The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity

Simon D. Pollett; Stephanie A. Richard; Anthony C. Fries; Mark P. Simons; Katrin Mende; Tahaniyat Lalani; Tida Lee; Sharon Chi; Rupal Mody; Cristian Madar; Anuradha Ganesan; Derek T. Larson; Christopher J. Colombo; Rhonda Colombo; Emily C. Samuels; Christopher C. Broder; Eric D. Laing; Darci R. Smith; David Tribble; Brian K. Agan; Timothy H. Burgess

doi:10.1093/cid/ciab543

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity

Simon D. Pollett^*, Stephanie A. Richard, Anthony C. Fries, Mark P. Simons, Katrin Mende, Tahaniyat Lalani, Tida Lee, Sharon Chi, Rupal Mody, Cristian Madar, Anuradha Ganesan, Derek T. Larson, Christopher J. Colombo, Rhonda Colombo, Emily C. Samuels, Christopher C. Broder, Eric D. Laing, Darci R. Smith, David Tribble, Brian K. AganTimothy H. Burgess

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Little is known about severe acute respiratory syndrome coronavirus 2 "vaccine-breakthrough"infections (VBIs). Here we characterize 24 VBIs in predominantly young healthy persons. While none required hospitalization, a proportion endorsed severe symptoms and shed live virus as high as 4.13 × 103 plaque-forming units/mL. Infecting genotypes included both variant-of-concern (VOC) and non-VOC strains.

Original language	English
Pages (from-to)	897-900
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	74
Issue number	5
DOIs	https://doi.org/10.1093/cid/ciab543
State	Published - 1 Mar 2022

Keywords

SARS-CoV-2
live virus
patient-reported outcomes
symptoms
vaccine breakthrough

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10.1093/cid/ciab543

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Pollett, S. D., Richard, S. A., Fries, A. C., Simons, M. P., Mende, K., Lalani, T., Lee, T., Chi, S., Mody, R., Madar, C., Ganesan, A., Larson, D. T., Colombo, C. J., Colombo, R., Samuels, E. C., Broder, C. C., Laing, E. D., Smith, D. R., Tribble, D., ... Burgess, T. H. (2022). The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity. Clinical Infectious Diseases, 74(5), 897-900. https://doi.org/10.1093/cid/ciab543

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abstract = "Little is known about severe acute respiratory syndrome coronavirus 2 {"}vaccine-breakthrough{"}infections (VBIs). Here we characterize 24 VBIs in predominantly young healthy persons. While none required hospitalization, a proportion endorsed severe symptoms and shed live virus as high as 4.13 × 103 plaque-forming units/mL. Infecting genotypes included both variant-of-concern (VOC) and non-VOC strains.",

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author = "Pollett, {Simon D.} and Richard, {Stephanie A.} and Fries, {Anthony C.} and Simons, {Mark P.} and Katrin Mende and Tahaniyat Lalani and Tida Lee and Sharon Chi and Rupal Mody and Cristian Madar and Anuradha Ganesan and Larson, {Derek T.} and Colombo, {Christopher J.} and Rhonda Colombo and Samuels, {Emily C.} and Broder, {Christopher C.} and Laing, {Eric D.} and Smith, {Darci R.} and David Tribble and Agan, {Brian K.} and Burgess, {Timothy H.}",

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doi = "10.1093/cid/ciab543",

language = "English",

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Pollett, SD , Richard, SA, Fries, AC, Simons, MP , Mende, K , Lalani, T, Lee, T, Chi, S, Mody, R, Madar, C, Ganesan, A, Larson, DT, Colombo, CJ , Colombo, R, Samuels, EC, Broder, CC , Laing, ED, Smith, DR, Tribble, D , Agan, BK & Burgess, TH 2022, 'The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity', Clinical Infectious Diseases, vol. 74, no. 5, pp. 897-900. https://doi.org/10.1093/cid/ciab543

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity. / Pollett, Simon D.; Richard, Stephanie A.; Fries, Anthony C. et al.
In: Clinical Infectious Diseases, Vol. 74, No. 5, 01.03.2022, p. 897-900.

Research output: Contribution to journal › Article › peer-review

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The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity

Abstract

Keywords

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