The spectra count label-free quantitation in cancer proteomics

Weidong Zhou*, Lance A. Liotta, Emanuel F. Petricoin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Mass spectrometry is used routinely for large-scale protein identification from complex biological mixtures. Recently, relative quantitation approach on the basis of spectra count has been applied in several cancer proteomic studies. In this review, we examine the mechanism of this technique and highlight several important parameters associated with its application.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalCancer Genomics and Proteomics
Issue number3
StatePublished - 2012
Externally publishedYes


  • Label-free quantitation
  • Mass spectrometry
  • Proteomics
  • Review
  • Spectra count


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