The spectra count label-free quantitation in cancer proteomics

Weidong Zhou; Lance A. Liotta; Emanuel F. Petricoin

The spectra count label-free quantitation in cancer proteomics

Weidong Zhou^*, Lance A. Liotta, Emanuel F. Petricoin

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Mass spectrometry is used routinely for large-scale protein identification from complex biological mixtures. Recently, relative quantitation approach on the basis of spectra count has been applied in several cancer proteomic studies. In this review, we examine the mechanism of this technique and highlight several important parameters associated with its application.

Original language	English
Pages (from-to)	135-142
Number of pages	8
Journal	Cancer Genomics and Proteomics
Volume	9
Issue number	3
State	Published - 2012
Externally published	Yes

Keywords

Label-free quantitation
Mass spectrometry
Proteomics
Review
Spectra count

Cite this

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title = "The spectra count label-free quantitation in cancer proteomics",

abstract = "Mass spectrometry is used routinely for large-scale protein identification from complex biological mixtures. Recently, relative quantitation approach on the basis of spectra count has been applied in several cancer proteomic studies. In this review, we examine the mechanism of this technique and highlight several important parameters associated with its application.",

keywords = "Label-free quantitation, Mass spectrometry, Proteomics, Review, Spectra count",

author = "Weidong Zhou and Liotta, {Lance A.} and Petricoin, {Emanuel F.}",

year = "2012",

language = "English",

volume = "9",

pages = "135--142",

journal = "Cancer Genomics and Proteomics",

issn = "1109-6535",

publisher = "International Institute of Anticancer Research",

number = "3",

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TY - JOUR

T1 - The spectra count label-free quantitation in cancer proteomics

AU - Zhou, Weidong

AU - Liotta, Lance A.

AU - Petricoin, Emanuel F.

PY - 2012

Y1 - 2012

N2 - Mass spectrometry is used routinely for large-scale protein identification from complex biological mixtures. Recently, relative quantitation approach on the basis of spectra count has been applied in several cancer proteomic studies. In this review, we examine the mechanism of this technique and highlight several important parameters associated with its application.

AB - Mass spectrometry is used routinely for large-scale protein identification from complex biological mixtures. Recently, relative quantitation approach on the basis of spectra count has been applied in several cancer proteomic studies. In this review, we examine the mechanism of this technique and highlight several important parameters associated with its application.

KW - Label-free quantitation

KW - Mass spectrometry

KW - Proteomics

KW - Review

KW - Spectra count

UR - http://www.scopus.com/inward/record.url?scp=84862516824&partnerID=8YFLogxK

M3 - Review article

C2 - 22593248

AN - SCOPUS:84862516824

SN - 1109-6535

VL - 9

SP - 135

EP - 142

JO - Cancer Genomics and Proteomics

JF - Cancer Genomics and Proteomics

IS - 3

ER -

The spectra count label-free quantitation in cancer proteomics

Abstract

Keywords

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