TY - JOUR
T1 - The spindle pole-body localization of activated cytoplasmic dynein is cell cycle-dependent in Aspergillus nidulans
AU - Bieger, Baronger Dowell
AU - Osmani, Aysha H.
AU - Xiang, Xin
AU - Egan, Martin J.
N1 - Publisher Copyright:
© 2021
PY - 2021/3
Y1 - 2021/3
N2 - Cytoplasmic dynein is a minus end-directed microtubule motor that can be activated by cargo adapters. In Aspergillus nidulans, overexpression of ΔC-HookA, the early endosomal adapter HookA missing its cargo-binding site, causes activated dynein to accumulate at septa and spindle pole bodies (SPBs) where the microtubule-organizing centers are located. Intriguingly, only some interphase nuclei show SPB signals of dynein. Here we present data demonstrating that localization of the activated dynein at SPBs is cell cycle-dependent: SPB dynein signals are seen to associate with nuclei at early G1 but disappear at about the G1-S boundary.
AB - Cytoplasmic dynein is a minus end-directed microtubule motor that can be activated by cargo adapters. In Aspergillus nidulans, overexpression of ΔC-HookA, the early endosomal adapter HookA missing its cargo-binding site, causes activated dynein to accumulate at septa and spindle pole bodies (SPBs) where the microtubule-organizing centers are located. Intriguingly, only some interphase nuclei show SPB signals of dynein. Here we present data demonstrating that localization of the activated dynein at SPBs is cell cycle-dependent: SPB dynein signals are seen to associate with nuclei at early G1 but disappear at about the G1-S boundary.
KW - Aspergillus nidulans
KW - Dynein
KW - Spindle-pole body
UR - http://www.scopus.com/inward/record.url?scp=85099610285&partnerID=8YFLogxK
U2 - 10.1016/j.fgb.2021.103519
DO - 10.1016/j.fgb.2021.103519
M3 - Article
C2 - 33472115
AN - SCOPUS:85099610285
SN - 1096-0937
VL - 148
JO - Fungal genetics and biology : FG & B
JF - Fungal genetics and biology : FG & B
M1 - 103519
ER -