TY - JOUR
T1 - The synthesis and toxicity of tripodal tricarbonyl rhenium complexes as radiopharmaceutical models
AU - Binkley, Sarah L.
AU - Barone, Natalie V.
AU - Underwood, Adam C.
AU - Milsted, Amy
AU - Franklin, Brenton R.
AU - Herrick, Richard S.
AU - Ziegler, Christopher J.
N1 - Funding Information:
The authors thank the University of Akron and the Ohio Board of Regents for funds used to carry out this research. We acknowledge NSF grant ( CHE-0116041 ) for funds to purchase the Bruker Nonius diffractometer. R.S.H. thanks the Research Corporation (CC6663/6616) for research support. We thank Dr. Yan Yun and his research group for time and training on the fluorescent microscope.
PY - 2010/6
Y1 - 2010/6
N2 - We report the synthesis and toxicity of a series of rhenium(I) tricarbonyl complexes incorporating the trisaminomethylethane (TAME) ligand. Compounds with the (TAME)Re(CO)3+ cation were synthesized via several routes, including by use of Re(CO)5X precursors as well as the aqueous cation Re(CO)3(H2O)3+. Salts of the formula [(TAME)Re(CO)3]X where X=Br-, Cl-, NO3-, PF6- and ClO4- were evaluated using two cell lines: the monoclonal S3 HeLa line and a vascular smooth muscle cell line harvested from mice. All compounds have isostructural cations and differ only in the identity of the non-coordinating anion. None of the complexes exhibited any appreciable toxicity in the HeLa line up to the solubility limit. In the vascular smooth muscle cell line, the bromide salt exhibited some cytotoxicity, but this observation most likely results from the presence of bromide anion, which has been shown to have limited toxicity.
AB - We report the synthesis and toxicity of a series of rhenium(I) tricarbonyl complexes incorporating the trisaminomethylethane (TAME) ligand. Compounds with the (TAME)Re(CO)3+ cation were synthesized via several routes, including by use of Re(CO)5X precursors as well as the aqueous cation Re(CO)3(H2O)3+. Salts of the formula [(TAME)Re(CO)3]X where X=Br-, Cl-, NO3-, PF6- and ClO4- were evaluated using two cell lines: the monoclonal S3 HeLa line and a vascular smooth muscle cell line harvested from mice. All compounds have isostructural cations and differ only in the identity of the non-coordinating anion. None of the complexes exhibited any appreciable toxicity in the HeLa line up to the solubility limit. In the vascular smooth muscle cell line, the bromide salt exhibited some cytotoxicity, but this observation most likely results from the presence of bromide anion, which has been shown to have limited toxicity.
KW - Re(CO)
KW - Rhenium
KW - Technetium
KW - Toxicity
KW - Trisaminomethylethane
UR - http://www.scopus.com/inward/record.url?scp=77952508792&partnerID=8YFLogxK
U2 - 10.1016/j.jinorgbio.2010.02.004
DO - 10.1016/j.jinorgbio.2010.02.004
M3 - Article
C2 - 20362340
AN - SCOPUS:77952508792
SN - 0162-0134
VL - 104
SP - 632
EP - 638
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
IS - 6
ER -