The Use of the Woodchuck as an Animal Model for Evaluation of Transarterial Embolization

Luke R. Wilkins; James R. Stone; Jaime Mata; Alisha Hawrylack; Ewa Kubicka; David L. Brautigan

doi:10.1016/j.jvir.2017.04.005

The Use of the Woodchuck as an Animal Model for Evaluation of Transarterial Embolization

Luke R. Wilkins^*, James R. Stone, Jaime Mata, Alisha Hawrylack, Ewa Kubicka, David L. Brautigan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

There are many shortcomings of current animal models as surrogates of hepatocellular carcinoma that handicap preclinical testing of embolization agents. The present study explores the feasibility of using the woodchuck (Marmota monax) as an animal model for the testing of novel embolization agents. Four woodchucks underwent magnetic resonance imaging, angiography, and left lobar hepatic artery particle embolization. Percutaneous access, arteriography, and lobar embolization were successful in all animals, with angiographic stasis obtained in the target vessel with minimal reflux of embolic material. These results support the feasibility of the woodchuck as an animal model for preclinical testing of embolization agents.

Original language	English
Pages (from-to)	1467-1471
Number of pages	5
Journal	Journal of Vascular and Interventional Radiology
Volume	28
Issue number	10
DOIs	https://doi.org/10.1016/j.jvir.2017.04.005
State	Published - Oct 2017
Externally published	Yes

Access to Document

10.1016/j.jvir.2017.04.005

Cite this

@article{1b77ab4bb0e34bceb9aa77c779fd999b,

title = "The Use of the Woodchuck as an Animal Model for Evaluation of Transarterial Embolization",

abstract = "There are many shortcomings of current animal models as surrogates of hepatocellular carcinoma that handicap preclinical testing of embolization agents. The present study explores the feasibility of using the woodchuck (Marmota monax) as an animal model for the testing of novel embolization agents. Four woodchucks underwent magnetic resonance imaging, angiography, and left lobar hepatic artery particle embolization. Percutaneous access, arteriography, and lobar embolization were successful in all animals, with angiographic stasis obtained in the target vessel with minimal reflux of embolic material. These results support the feasibility of the woodchuck as an animal model for preclinical testing of embolization agents.",

author = "Wilkins, {Luke R.} and Stone, {James R.} and Jaime Mata and Alisha Hawrylack and Ewa Kubicka and Brautigan, {David L.}",

note = "Publisher Copyright: {\textcopyright} 2017 SIR",

year = "2017",

month = oct,

doi = "10.1016/j.jvir.2017.04.005",

language = "English",

volume = "28",

pages = "1467--1471",

journal = "Journal of Vascular and Interventional Radiology",

issn = "1051-0443",

number = "10",

}

TY - JOUR

T1 - The Use of the Woodchuck as an Animal Model for Evaluation of Transarterial Embolization

AU - Wilkins, Luke R.

AU - Stone, James R.

AU - Mata, Jaime

AU - Hawrylack, Alisha

AU - Kubicka, Ewa

AU - Brautigan, David L.

PY - 2017/10

Y1 - 2017/10

N2 - There are many shortcomings of current animal models as surrogates of hepatocellular carcinoma that handicap preclinical testing of embolization agents. The present study explores the feasibility of using the woodchuck (Marmota monax) as an animal model for the testing of novel embolization agents. Four woodchucks underwent magnetic resonance imaging, angiography, and left lobar hepatic artery particle embolization. Percutaneous access, arteriography, and lobar embolization were successful in all animals, with angiographic stasis obtained in the target vessel with minimal reflux of embolic material. These results support the feasibility of the woodchuck as an animal model for preclinical testing of embolization agents.

AB - There are many shortcomings of current animal models as surrogates of hepatocellular carcinoma that handicap preclinical testing of embolization agents. The present study explores the feasibility of using the woodchuck (Marmota monax) as an animal model for the testing of novel embolization agents. Four woodchucks underwent magnetic resonance imaging, angiography, and left lobar hepatic artery particle embolization. Percutaneous access, arteriography, and lobar embolization were successful in all animals, with angiographic stasis obtained in the target vessel with minimal reflux of embolic material. These results support the feasibility of the woodchuck as an animal model for preclinical testing of embolization agents.

UR - http://www.scopus.com/inward/record.url?scp=85031709411&partnerID=8YFLogxK

U2 - 10.1016/j.jvir.2017.04.005

DO - 10.1016/j.jvir.2017.04.005

M3 - Article

C2 - 28941521

AN - SCOPUS:85031709411

SN - 1051-0443

VL - 28

SP - 1467

EP - 1471

JO - Journal of Vascular and Interventional Radiology

JF - Journal of Vascular and Interventional Radiology

IS - 10

ER -

The Use of the Woodchuck as an Animal Model for Evaluation of Transarterial Embolization

Abstract

Access to Document

Fingerprint

Cite this