The Use of Tramadol for Acute Heroin Withdrawal: A Comparison to Clonidine

Paul W. Sobey; Theodore V. Parran; Scott F. Grey; Christopher L. Adelman; Jaehak Yu

doi:10.1300/J069v22n04_03

The Use of Tramadol for Acute Heroin Withdrawal: A Comparison to Clonidine

Paul W. Sobey
, Theodore V. Parran^*
, Scott F. Grey
, Christopher L. Adelman
, Jaehak Yu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Using a retrospective chart review, 59 patients detoxified with tramadol were compared to 85 patients detoxified with clonidine on rates of leaving against medical advice (AMA) and control of withdrawal symptoms. Patients detoxified with tramadol had 23% (95% CI, 0.09-0.59; P < .01) the risk of leaving AMA and scored an average of 0.24 points lower (95% CI, 0.08-0.41; P < .01) on a 0-3 point withdrawal symptom scale compared to patients detoxified with clonidine. This preliminary study indicates that tramadol is more effective in managing withdrawal than clonidine, and may be especially useful in outpatient detoxification.

Original language	English
Pages (from-to)	13-25
Number of pages	13
Journal	Journal of Addictive Diseases
Volume	22
Issue number	4
DOIs	https://doi.org/10.1300/J069v22n04_03
State	Published - 2003
Externally published	Yes

Keywords

Clonidine therapeutic use
Cohort studies
Drug
Heroin dependence drug therapy
Medical detoxification
Tramadol therapeutic use

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10.1300/J069v22n04_03

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@article{9cf4c8e5a1244640ab283a8ec6b948c1,

title = "The Use of Tramadol for Acute Heroin Withdrawal: A Comparison to Clonidine",

abstract = "Using a retrospective chart review, 59 patients detoxified with tramadol were compared to 85 patients detoxified with clonidine on rates of leaving against medical advice (AMA) and control of withdrawal symptoms. Patients detoxified with tramadol had 23\% (95\% CI, 0.09-0.59; P < .01) the risk of leaving AMA and scored an average of 0.24 points lower (95\% CI, 0.08-0.41; P < .01) on a 0-3 point withdrawal symptom scale compared to patients detoxified with clonidine. This preliminary study indicates that tramadol is more effective in managing withdrawal than clonidine, and may be especially useful in outpatient detoxification.",

keywords = "Clonidine therapeutic use, Cohort studies, Drug, Heroin dependence drug therapy, Medical detoxification, Tramadol therapeutic use",

author = "Sobey, \{Paul W.\} and Parran, \{Theodore V.\} and Grey, \{Scott F.\} and Adelman, \{Christopher L.\} and Jaehak Yu",

note = "Funding Information: Funding support was provided by the Cuyahoga County Alcohol and Drug Addiction Services Board; the Department of Family Medicine at University Hospitals of Cleveland, Ohio; the Veteran Administration Special Fellowships in Substance Abuse and the Center for Substance Abuse Prevention.",

year = "2003",

doi = "10.1300/J069v22n04\_03",

language = "English",

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journal = "Journal of Addictive Diseases",

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T2 - A Comparison to Clonidine

AU - Sobey, Paul W.

AU - Parran, Theodore V.

AU - Grey, Scott F.

AU - Adelman, Christopher L.

AU - Yu, Jaehak

N1 - Funding Information: Funding support was provided by the Cuyahoga County Alcohol and Drug Addiction Services Board; the Department of Family Medicine at University Hospitals of Cleveland, Ohio; the Veteran Administration Special Fellowships in Substance Abuse and the Center for Substance Abuse Prevention.

PY - 2003

Y1 - 2003

N2 - Using a retrospective chart review, 59 patients detoxified with tramadol were compared to 85 patients detoxified with clonidine on rates of leaving against medical advice (AMA) and control of withdrawal symptoms. Patients detoxified with tramadol had 23% (95% CI, 0.09-0.59; P < .01) the risk of leaving AMA and scored an average of 0.24 points lower (95% CI, 0.08-0.41; P < .01) on a 0-3 point withdrawal symptom scale compared to patients detoxified with clonidine. This preliminary study indicates that tramadol is more effective in managing withdrawal than clonidine, and may be especially useful in outpatient detoxification.

AB - Using a retrospective chart review, 59 patients detoxified with tramadol were compared to 85 patients detoxified with clonidine on rates of leaving against medical advice (AMA) and control of withdrawal symptoms. Patients detoxified with tramadol had 23% (95% CI, 0.09-0.59; P < .01) the risk of leaving AMA and scored an average of 0.24 points lower (95% CI, 0.08-0.41; P < .01) on a 0-3 point withdrawal symptom scale compared to patients detoxified with clonidine. This preliminary study indicates that tramadol is more effective in managing withdrawal than clonidine, and may be especially useful in outpatient detoxification.

KW - Clonidine therapeutic use

KW - Cohort studies

KW - Drug

KW - Heroin dependence drug therapy

KW - Medical detoxification

KW - Tramadol therapeutic use

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JO - Journal of Addictive Diseases

JF - Journal of Addictive Diseases

IS - 4

ER -

The Use of Tramadol for Acute Heroin Withdrawal: A Comparison to Clonidine

Abstract

Keywords

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