The use of urinary bladder matrix in the treatment of trauma and combat casualty wound care

Ian L. Valerio*, Paul Campbell, Jennifer Sabino, Christopher L. Dearth, Mark Fleming

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Treatment of combat injuries and resulting wounds can be difficult to treat due to compromised and evolving tissue necrosis, environmental contaminants, multidrug resistant microbacterial and/or fungal infections, coupled with microvascular damage and/or hypovascularized exposed vital structures. Our group has developed surgical care algorithms with identifiable salvage techniques to achieve stable, definitive wound coverage often with the aid of certain regenerative medicine biologic scaffold materials and advanced wound care to facilitate tissue coverage and healing. This case series reports on the role of urinary bladder matrix scaffolds in the wound care and reconstruction of traumatic and combat wounds. Urinary bladder matrix was found to facilitate definitive soft tissue reconstruction by establishing a neovascularized soft tissue base acceptable for second stage wound and skin coverage options within traumatic and combat-related wounds.

Original languageEnglish
Pages (from-to)611-622
Number of pages12
JournalRegenerative Medicine
Issue number5
StatePublished - 1 Aug 2015
Externally publishedYes


  • biologic scaffolds
  • combat casualty care
  • extracellular matrix (ECM)
  • extremity trauma
  • limb salvage
  • regenerative medicine
  • soft tissue regenerate
  • urinary bladder matrix (UBM)
  • vascularized wound bed


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