Therapeutic Utility of Cold-Stored Platelets or Cold-Stored Whole Blood for the Bleeding Hematology-Oncology Patient

Thomas G. Scorer; Kristin M. Reddoch-Cardenas; Kimberly A. Thomas; Andrew P. Cap; Philip C. Spinella

doi:10.1016/j.hoc.2019.05.012

Therapeutic Utility of Cold-Stored Platelets or Cold-Stored Whole Blood for the Bleeding Hematology-Oncology Patient

Thomas G. Scorer^*, Kristin M. Reddoch-Cardenas, Kimberly A. Thomas, Andrew P. Cap, Philip C. Spinella

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Bleeding related to thrombocytopenia is common in hematology-oncology patients. Platelets stored at room temperature (RTPs) are the current standard of care. Platelets stored in the cold (CSPs) have enhanced hemostatic function relative to RTPs. CSPs were reported to reduce bleeding in hematology-oncology patients. Recent studies have confirmed the enhanced hemostatic properties of CSPs. CSPs may be the better therapeutic option for this population. CSPs may also offer a preferable immune profile, reduced thrombotic risk, and reduced transfusion-transmitted infection risk. The logistical advantages of CSPs would improve outcomes for many patients who currently cannot access platelet transfusions.

Original language	English
Pages (from-to)	873-885
Number of pages	13
Journal	Hematology/Oncology Clinics of North America
Volume	33
Issue number	5
DOIs	https://doi.org/10.1016/j.hoc.2019.05.012
State	Published - Oct 2019
Externally published	Yes

Keywords

Bleeding
Cold-stored platelets
Oncology
Platelet storage
Platelet transfusion
Thrombocytopenia

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10.1016/j.hoc.2019.05.012

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title = "Therapeutic Utility of Cold-Stored Platelets or Cold-Stored Whole Blood for the Bleeding Hematology-Oncology Patient",

abstract = "Bleeding related to thrombocytopenia is common in hematology-oncology patients. Platelets stored at room temperature (RTPs) are the current standard of care. Platelets stored in the cold (CSPs) have enhanced hemostatic function relative to RTPs. CSPs were reported to reduce bleeding in hematology-oncology patients. Recent studies have confirmed the enhanced hemostatic properties of CSPs. CSPs may be the better therapeutic option for this population. CSPs may also offer a preferable immune profile, reduced thrombotic risk, and reduced transfusion-transmitted infection risk. The logistical advantages of CSPs would improve outcomes for many patients who currently cannot access platelet transfusions.",

keywords = "Bleeding, Cold-stored platelets, Oncology, Platelet storage, Platelet transfusion, Thrombocytopenia",

author = "Scorer, {Thomas G.} and Reddoch-Cardenas, {Kristin M.} and Thomas, {Kimberly A.} and Cap, {Andrew P.} and Spinella, {Philip C.}",

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year = "2019",

month = oct,

doi = "10.1016/j.hoc.2019.05.012",

language = "English",

volume = "33",

pages = "873--885",

journal = "Hematology/Oncology Clinics of North America",

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T1 - Therapeutic Utility of Cold-Stored Platelets or Cold-Stored Whole Blood for the Bleeding Hematology-Oncology Patient

AU - Scorer, Thomas G.

AU - Reddoch-Cardenas, Kristin M.

AU - Thomas, Kimberly A.

AU - Cap, Andrew P.

AU - Spinella, Philip C.

PY - 2019/10

Y1 - 2019/10

N2 - Bleeding related to thrombocytopenia is common in hematology-oncology patients. Platelets stored at room temperature (RTPs) are the current standard of care. Platelets stored in the cold (CSPs) have enhanced hemostatic function relative to RTPs. CSPs were reported to reduce bleeding in hematology-oncology patients. Recent studies have confirmed the enhanced hemostatic properties of CSPs. CSPs may be the better therapeutic option for this population. CSPs may also offer a preferable immune profile, reduced thrombotic risk, and reduced transfusion-transmitted infection risk. The logistical advantages of CSPs would improve outcomes for many patients who currently cannot access platelet transfusions.

AB - Bleeding related to thrombocytopenia is common in hematology-oncology patients. Platelets stored at room temperature (RTPs) are the current standard of care. Platelets stored in the cold (CSPs) have enhanced hemostatic function relative to RTPs. CSPs were reported to reduce bleeding in hematology-oncology patients. Recent studies have confirmed the enhanced hemostatic properties of CSPs. CSPs may be the better therapeutic option for this population. CSPs may also offer a preferable immune profile, reduced thrombotic risk, and reduced transfusion-transmitted infection risk. The logistical advantages of CSPs would improve outcomes for many patients who currently cannot access platelet transfusions.

KW - Bleeding

KW - Cold-stored platelets

KW - Oncology

KW - Platelet storage

KW - Platelet transfusion

KW - Thrombocytopenia

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U2 - 10.1016/j.hoc.2019.05.012

DO - 10.1016/j.hoc.2019.05.012

M3 - Review article

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AN - SCOPUS:85068356685

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JO - Hematology/Oncology Clinics of North America

JF - Hematology/Oncology Clinics of North America

IS - 5

ER -

Therapeutic Utility of Cold-Stored Platelets or Cold-Stored Whole Blood for the Bleeding Hematology-Oncology Patient

Abstract

Keywords

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