Thrombotic Thrombocytopenic Purpura in HIV-Infected Patients

David L. Blazes*, Catherine F. Decker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Thrombocytopenia is one of the most common hematologic abnormalities seen in patients infected with the human immunodeficiency virus (HIV). Because HIV-infected patients have a higher incidence of immune-related thrombocytopenia, the laboratory and clinical features of thrombotic thrombocytopenic purpura (TTP) may be overlooked and the diagnosis never considered. The clinical course and treatment of these entities are distinctly different. Early diagnosis and appropriate therapy with plasma exchange therapy may be lifesaving. Outcome and survival with TTP may be related to the stage of HIV infection and the severity of immunosuppression at the time of the diagnosis. The effect that highly active antiretroviral therapy (HAART) will have on the incidence of TTP remains to be seen. Reviewed are 7 episodes of TTP that occurred in 5 patients we cared for along with the literature pertaining to this topic.

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalInfectious Diseases in Clinical Practice
Issue number2
StatePublished - Mar 2004


Dive into the research topics of 'Thrombotic Thrombocytopenic Purpura in HIV-Infected Patients'. Together they form a unique fingerprint.

Cite this