Time Matters: Importance of Circadian Rhythms, Disruption, and Chronotherapy in Urologic Malignancies

Sierra T. Pence; Gregory T. Chesnut; Ayesha A. Shafi

doi:10.1016/j.urology.2023.01.009

Time Matters: Importance of Circadian Rhythms, Disruption, and Chronotherapy in Urologic Malignancies

Sierra T. Pence, Gregory T. Chesnut, Ayesha A. Shafi^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

The human body was evolutionarily programmed to run on cycles, termed circadian rhythms, which integrate human behavior and bodily function with the environment. Disruptions to these rhythms via desynchronization have been deemed a probable carcinogen by the WHO. Subsequent research has identified alterations in multiple core clock genes when comparing tumor and benign tissues. This review will discuss core clock genes associated with urogenital malignancies and highlight impactful research regarding circadian biology use in treatment. Chronotherapy, treatment alignment with an individual's biological rhythm, remains a relatively untouched field within urology that should be explored to possibly enhance therapeutic outcomes.

Original language	English
Pages (from-to)	6-12
Number of pages	7
Journal	Urology
Volume	175
DOIs	https://doi.org/10.1016/j.urology.2023.01.009
State	Published - May 2023
Externally published	Yes

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10.1016/j.urology.2023.01.009

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title = "Time Matters: Importance of Circadian Rhythms, Disruption, and Chronotherapy in Urologic Malignancies",

abstract = "The human body was evolutionarily programmed to run on cycles, termed circadian rhythms, which integrate human behavior and bodily function with the environment. Disruptions to these rhythms via desynchronization have been deemed a probable carcinogen by the WHO. Subsequent research has identified alterations in multiple core clock genes when comparing tumor and benign tissues. This review will discuss core clock genes associated with urogenital malignancies and highlight impactful research regarding circadian biology use in treatment. Chronotherapy, treatment alignment with an individual's biological rhythm, remains a relatively untouched field within urology that should be explored to possibly enhance therapeutic outcomes.",

author = "Pence, {Sierra T.} and Chesnut, {Gregory T.} and Shafi, {Ayesha A.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

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doi = "10.1016/j.urology.2023.01.009",

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AU - Chesnut, Gregory T.

AU - Shafi, Ayesha A.

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AB - The human body was evolutionarily programmed to run on cycles, termed circadian rhythms, which integrate human behavior and bodily function with the environment. Disruptions to these rhythms via desynchronization have been deemed a probable carcinogen by the WHO. Subsequent research has identified alterations in multiple core clock genes when comparing tumor and benign tissues. This review will discuss core clock genes associated with urogenital malignancies and highlight impactful research regarding circadian biology use in treatment. Chronotherapy, treatment alignment with an individual's biological rhythm, remains a relatively untouched field within urology that should be explored to possibly enhance therapeutic outcomes.

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DO - 10.1016/j.urology.2023.01.009

M3 - Review article

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JO - Urology

JF - Urology

ER -

Time Matters: Importance of Circadian Rhythms, Disruption, and Chronotherapy in Urologic Malignancies

Abstract

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