Tissue engineering and regenerative medicine approaches to enhance the functional response to skeletal muscle injury

Brian M. Sicari, Christopher L. Dearth, Stephen F. Badylak*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

The well-recognized ability of skeletal muscle for functional and structural regeneration following injury is severely compromised in degenerative diseases and in volumetric muscle loss. Tissue engineering and regenerative medicine strategies to support muscle reconstruction have typically been cell-centric with approaches that involve the exogenous delivery of cells with myogenic potential. These strategies have been limited by poor cell viability and engraftment into host tissue. Alternative approaches have involved the use of biomaterial scaffolds as substrates or delivery vehicles for exogenous myogenic progenitor cells. Acellular biomaterial scaffolds composed of mammalian extracellular matrix (ECM) have also been used as an inductive niche to promote the recruitment and differentiation of endogenous myogenic progenitor cells. An acellular approach, which activates or utilizes endogenous cell sources, obviates the need for exogenous cell administration and provides an advantage for clinical translation. The present review examines the state of tissue engineering and regenerative medicine therapies directed at augmenting the skeletal muscle response to injury and presents the pros and cons of each with respect to clinical translation.

Original languageEnglish
Pages (from-to)51-64
Number of pages14
JournalAnatomical Record
Volume297
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • Biologic scaffolds
  • Regenerative medicine
  • Stem cells
  • Tissue engineering

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