Tissues from population-based cancer registries: A novel approach to increasing research potential

Marc T. Goodman*, Brenda Y. Hernandez, Stephen Hewitt, Charles F. Lynch, Timothy R. Coté, Henry F. Frierson, Christopher A. Moskaluk, Jeffrey L. Killeen, Wendy Cozen, Charles R. Key, Limin Clegg, Marsha Reichman, Benjamin F. Hankey, Brenda Edwards

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Population-based cancer registries, such as those included in the Surveillance, Epidemiology, and End-Results (SEER) Program, offer tremendous research potential beyond traditional surveillance activities. We describe the expansion of SEER registries to gather formalin-fixed, paraffin-embedded tissue from cancer patients on a population basis. Population-based tissue banks have the advantage of providing an unbiased sampling frame for evaluating the public health impact of genes or protein targets that may be used for therapeutic or diagnostic purposes in defined communities. Such repositories provide a unique resource for testing new molecular classification schemes for cancer, validating new biologic markers of malignancy, prognosis and progression, assessing therapeutic targets, and measuring allele frequencies of cancer-associated genetic polymorphisms or germline mutations in representative samples. The assembly of tissue microarrays will allow for the use of rapid, large-scale protein-expression profiling of tumor samples while limiting depletion of this valuable resource. Access to biologic specimens through SEER registries will provide researchers with demographic, clinical, and risk factor information on cancer patients with assured data quality and completeness. Clinical outcome data, such as disease-free survival, can be correlated with previously validated prognostic markers. Furthermore, the anonymity of the study subject can be protected through rigorous standards of confidentiality. SEER-based tissue resources represent a step forward in true, population-based tissue repositories of tumors from US patients and may serve as a foundation for molecular epidemiology studies of cancer in this country.

Original languageEnglish
Pages (from-to)812-820
Number of pages9
JournalHuman Pathology
Issue number7
StatePublished - Jul 2005
Externally publishedYes


  • Cancer registry
  • Neoplasm
  • SEER Program
  • Tissue bank
  • Tissue microarray


Dive into the research topics of 'Tissues from population-based cancer registries: A novel approach to increasing research potential'. Together they form a unique fingerprint.

Cite this