TMEM173 Drives Lethal Coagulation in Sepsis

Hui Zhang; Ling Zeng; Min Xie; Jiao Liu; Borong Zhou; Runliu Wu; Lizhi Cao; Guido Kroemer; Haichao Wang; Timothy R. Billiar; Herbert J. Zeh; Rui Kang; Jianxin Jiang; Yan Yu; Daolin Tang

doi:10.1016/j.chom.2020.02.004

TMEM173 Drives Lethal Coagulation in Sepsis

Hui Zhang, Ling Zeng, Min Xie, Jiao Liu, Borong Zhou, Runliu Wu, Lizhi Cao, Guido Kroemer, Haichao Wang, Timothy R. Billiar, Herbert J. Zeh, Rui Kang, Jianxin Jiang^*, Yan Yu, Daolin Tang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

Abstract

Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.

Original language	English
Pages (from-to)	556-570.e6
Journal	Cell Host and Microbe
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2020.02.004
State	Published - 8 Apr 2020
Externally published	Yes

Keywords

ER stress
GSDMD
STING
TMEM173
calcium
coagulation
inflammasome
pyroptosis
sepsis
tissue factor

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10.1016/j.chom.2020.02.004

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title = "TMEM173 Drives Lethal Coagulation in Sepsis",

abstract = "Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.",

keywords = "ER stress, GSDMD, STING, TMEM173, calcium, coagulation, inflammasome, pyroptosis, sepsis, tissue factor",

author = "Hui Zhang and Ling Zeng and Min Xie and Jiao Liu and Borong Zhou and Runliu Wu and Lizhi Cao and Guido Kroemer and Haichao Wang and Billiar, {Timothy R.} and Zeh, {Herbert J.} and Rui Kang and Jianxin Jiang and Yan Yu and Daolin Tang",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = apr,

day = "8",

doi = "10.1016/j.chom.2020.02.004",

language = "English",

volume = "27",

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T1 - TMEM173 Drives Lethal Coagulation in Sepsis

AU - Zhang, Hui

AU - Zeng, Ling

AU - Xie, Min

AU - Liu, Jiao

AU - Zhou, Borong

AU - Wu, Runliu

AU - Cao, Lizhi

AU - Kroemer, Guido

AU - Wang, Haichao

AU - Billiar, Timothy R.

AU - Zeh, Herbert J.

AU - Kang, Rui

AU - Jiang, Jianxin

AU - Yu, Yan

AU - Tang, Daolin

PY - 2020/4/8

Y1 - 2020/4/8

N2 - Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.

AB - Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.

KW - ER stress

KW - GSDMD

KW - STING

KW - TMEM173

KW - calcium

KW - coagulation

KW - inflammasome

KW - pyroptosis

KW - sepsis

KW - tissue factor

UR - http://www.scopus.com/inward/record.url?scp=85082829921&partnerID=8YFLogxK

U2 - 10.1016/j.chom.2020.02.004

DO - 10.1016/j.chom.2020.02.004

M3 - Article

C2 - 32142632

AN - SCOPUS:85082829921

SN - 1931-3128

VL - 27

SP - 556-570.e6

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 4

ER -

TMEM173 Drives Lethal Coagulation in Sepsis

Abstract

Keywords

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