TMEM173 Drives Lethal Coagulation in Sepsis

Hui Zhang, Ling Zeng, Min Xie, Jiao Liu, Borong Zhou, Runliu Wu, Lizhi Cao, Guido Kroemer, Haichao Wang, Timothy R. Billiar, Herbert J. Zeh, Rui Kang, Jianxin Jiang*, Yan Yu, Daolin Tang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.

Original languageEnglish
Pages (from-to)556-570.e6
JournalCell Host and Microbe
Volume27
Issue number4
DOIs
StatePublished - 8 Apr 2020
Externally publishedYes

Keywords

  • ER stress
  • GSDMD
  • STING
  • TMEM173
  • calcium
  • coagulation
  • inflammasome
  • pyroptosis
  • sepsis
  • tissue factor

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