@article{6aaeb443dd684677b2bd1a45aa4bd250,
title = "TMEM173 Drives Lethal Coagulation in Sepsis",
abstract = "Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.",
keywords = "ER stress, GSDMD, STING, TMEM173, calcium, coagulation, inflammasome, pyroptosis, sepsis, tissue factor",
author = "Hui Zhang and Ling Zeng and Min Xie and Jiao Liu and Borong Zhou and Runliu Wu and Lizhi Cao and Guido Kroemer and Haichao Wang and Billiar, {Timothy R.} and Zeh, {Herbert J.} and Rui Kang and Jianxin Jiang and Yan Yu and Daolin Tang",
note = "Funding Information: We thank Dave Primm (Department of Surgery, University of Texas Southwestern Medical Center) for his critical reading of the manuscript. H.W. is supported by grants from the US National Institutes of Health ( R01GM063075 and R01AT005076 ). T.B. is supported by a grant from the US National Institutes of Health ( R35GM127027 ). G.K. is supported by the Ligue contre le Cancer ({\'e}quipe labelis{\'e}e); Agence National de la Recherche (ANR) – Projets blancs; ANR under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases; Association pour la recherch{\'e} sur le cancer (ARC); Canc{\'e}rop{\^o}le Ile-de-France; Chancelerie des universit{\'e}s de Paris (Legs Poix), Fondation pour la Recherche M{\'e}dicale (FRM); a donation by Elior; European Research Area Network on Cardiovascular Diseases (ERA-CVD, MINOTAUR); Gustave Roussy Odyssea, the European Union Horizon 2020 Project Oncobiome; Fondation Carrefour; High-end Foreign Expert Program in China ( GDW20171100085 and GDW20181100051 ); Institut National du Cancer (INCa); Inserm (HTE); Institut Universitaire de France; LeDucq Foundation; the LabEx Immuno-Oncology; the RHU Torino Lumi{\`e}re; the Seerave Foundation; the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); and the SIRIC Cancer Research and Personalized Medicine (CARPEM). J.L. is supported by grants from the National Natural Science Foundation of China ( 81830048 ). J.J. is supported by grants from the National Natural Science Foundation of China ( 81530063 ). L.Z. is supported by the Excellent Youth Grant of State Key Laboratory of Trauma, Burns, and Combined Injury of China ( SKLYQ201901 ). Funding Information: We thank Dave Primm (Department of Surgery, University of Texas Southwestern Medical Center) for his critical reading of the manuscript. H.W. is supported by grants from the US National Institutes of Health (R01GM063075 and R01AT005076). T.B. is supported by a grant from the US National Institutes of Health (R35GM127027). G.K. is supported by the Ligue contre le Cancer (?quipe labelis?e); Agence National de la Recherche (ANR) ? Projets blancs; ANR under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases; Association pour la recherch? sur le cancer (ARC); Canc?rop?le Ile-de-France; Chancelerie des universit?s de Paris (Legs Poix), Fondation pour la Recherche M?dicale (FRM); a donation by Elior; European Research Area Network on Cardiovascular Diseases (ERA-CVD, MINOTAUR); Gustave Roussy Odyssea, the European Union Horizon 2020 Project Oncobiome; Fondation Carrefour; High-end Foreign Expert Program in China (GDW20171100085 and GDW20181100051); Institut National du Cancer (INCa); Inserm (HTE); Institut Universitaire de France; LeDucq Foundation; the LabEx Immuno-Oncology; the RHU Torino Lumi?re; the Seerave Foundation; the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE); and the SIRIC Cancer Research and Personalized Medicine (CARPEM). J.L. is supported by grants from the National Natural Science Foundation of China (81830048). J.J. is supported by grants from the National Natural Science Foundation of China (81530063). L.Z. is supported by the Excellent Youth Grant of State Key Laboratory of Trauma, Burns, and Combined Injury of China (SKLYQ201901). D.T. Y.Y. and J.J. designed the experiments. H.Z. L.Z. M.X. J.L. B.Z. R.W. R.K. L.C. J.J. Y.Y. and D.T. conducted the experiments. D.T. wrote the paper. G.K. H.W. H.J.Z. and T.R.B. provided reagents or edited the manuscript. The authors declare no conflicts of interest or financial interests. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = apr,
day = "8",
doi = "10.1016/j.chom.2020.02.004",
language = "English",
volume = "27",
pages = "556--570.e6",
journal = "Cell Host and Microbe",
issn = "1931-3128",
number = "4",
}