TMEM173 Drives Lethal Coagulation in Sepsis

Hui Zhang; Ling Zeng; Min Xie; Jiao Liu; Borong Zhou; Runliu Wu; Lizhi Cao; Guido Kroemer; Haichao Wang; Timothy R. Billiar; Herbert J. Zeh; Rui Kang; Jianxin Jiang; Yan Yu; Daolin Tang

doi:10.1016/j.chom.2020.02.004

TMEM173 Drives Lethal Coagulation in Sepsis

Hui Zhang
, Ling Zeng
, Min Xie
, Jiao Liu
, Borong Zhou
, Runliu Wu
, Lizhi Cao
, Guido Kroemer
, Haichao Wang
, Timothy R. Billiar
, Herbert J. Zeh
, Rui Kang
, Jianxin Jiang^*
, Yan Yu
, Daolin Tang

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Article › peer-review

180 Scopus citations

Abstract

Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.

Original language	English
Pages (from-to)	556-570.e6
Journal	Cell Host and Microbe
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2020.02.004
State	Published - 8 Apr 2020

Keywords

ER stress
GSDMD
STING
TMEM173
calcium
coagulation
inflammasome
pyroptosis
sepsis
tissue factor

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10.1016/j.chom.2020.02.004

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@article{6aaeb443dd684677b2bd1a45aa4bd250,

title = "TMEM173 Drives Lethal Coagulation in Sepsis",

abstract = "Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.",

keywords = "ER stress, GSDMD, STING, TMEM173, calcium, coagulation, inflammasome, pyroptosis, sepsis, tissue factor",

author = "Hui Zhang and Ling Zeng and Min Xie and Jiao Liu and Borong Zhou and Runliu Wu and Lizhi Cao and Guido Kroemer and Haichao Wang and Billiar, \{Timothy R.\} and Zeh, \{Herbert J.\} and Rui Kang and Jianxin Jiang and Yan Yu and Daolin Tang",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = apr,

day = "8",

doi = "10.1016/j.chom.2020.02.004",

language = "English",

volume = "27",

pages = "556--570.e6",

journal = "Cell Host and Microbe",

issn = "1931-3128",

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TY - JOUR

T1 - TMEM173 Drives Lethal Coagulation in Sepsis

AU - Zhang, Hui

AU - Zeng, Ling

AU - Xie, Min

AU - Liu, Jiao

AU - Zhou, Borong

AU - Wu, Runliu

AU - Cao, Lizhi

AU - Kroemer, Guido

AU - Wang, Haichao

AU - Billiar, Timothy R.

AU - Zeh, Herbert J.

AU - Kang, Rui

AU - Jiang, Jianxin

AU - Yu, Yan

AU - Tang, Daolin

PY - 2020/4/8

Y1 - 2020/4/8

N2 - Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.

AB - Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.

KW - ER stress

KW - GSDMD

KW - STING

KW - TMEM173

KW - calcium

KW - coagulation

KW - inflammasome

KW - pyroptosis

KW - sepsis

KW - tissue factor

UR - https://www.scopus.com/pages/publications/85082829921

U2 - 10.1016/j.chom.2020.02.004

DO - 10.1016/j.chom.2020.02.004

M3 - Article

C2 - 32142632

AN - SCOPUS:85082829921

SN - 1931-3128

VL - 27

SP - 556-570.e6

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 4

ER -

TMEM173 Drives Lethal Coagulation in Sepsis

Abstract

Keywords

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