TNFα G308A genotype, resilience to sleep deprivation, and the effect of caffeine on psychomotor vigilance performance in a randomized, double-blind, placebo-controlled, crossover study

Lillian Skeiky; Allison J. Brager; Brieann C. Satterfield; Martha Petrovick; Thomas J. Balkin; Vincent F. Capaldi; Ruthie H. Ratcliffe; Hans P.A. Van Dongen; Devon A. Hansen

doi:10.1080/07420528.2020.1821044

TNFα G308A genotype, resilience to sleep deprivation, and the effect of caffeine on psychomotor vigilance performance in a randomized, double-blind, placebo-controlled, crossover study

Lillian Skeiky, Allison J. Brager, Brieann C. Satterfield, Martha Petrovick, Thomas J. Balkin, Vincent F. Capaldi, Ruthie H. Ratcliffe, Hans P.A. Van Dongen, Devon A. Hansen^*

^*Corresponding author for this work

Psychiatry

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The TNFα G308A gene polymorphism has been reported to influence performance impairment during total sleep deprivation (TSD). We investigated this effect in a randomized, double-blind, crossover laboratory study of repeated exposure to 48 h TSD with caffeine administration at different doses. In a retrospective analysis, we replicated the finding that the A allele of TNFα G308A, found in 4 of 12 study participants, confers resilience to performance impairment during TSD. There was no evidence of an interaction of TNFα genotype with the beneficial effect of caffeine (200 or 300 mg) on performance during TSD, suggesting distinct underlying mechanisms.

Original language	English
Pages (from-to)	1461-1464
Number of pages	4
Journal	Chronobiology International
Volume	37
Issue number	9-10
DOIs	https://doi.org/10.1080/07420528.2020.1821044
State	Published - 2020

Keywords

caffeine gum
Cognitive impairment
dose response
fatigue
phenotype
psychomotor vigilance test (PVT)
single nucleotide polymorphism
within-subjects design

Access to Document

10.1080/07420528.2020.1821044

Cite this

Skeiky, L., Brager, A. J., Satterfield, B. C., Petrovick, M., Balkin, T. J., Capaldi, V. F., Ratcliffe, R. H., Van Dongen, H. P. A., & Hansen, D. A. (2020). TNFα G308A genotype, resilience to sleep deprivation, and the effect of caffeine on psychomotor vigilance performance in a randomized, double-blind, placebo-controlled, crossover study. Chronobiology International, 37(9-10), 1461-1464. https://doi.org/10.1080/07420528.2020.1821044

@article{65a7182f174643c6959f6bc20db9f991,

title = " TNFα G308A genotype, resilience to sleep deprivation, and the effect of caffeine on psychomotor vigilance performance in a randomized, double-blind, placebo-controlled, crossover study",

abstract = "The TNFα G308A gene polymorphism has been reported to influence performance impairment during total sleep deprivation (TSD). We investigated this effect in a randomized, double-blind, crossover laboratory study of repeated exposure to 48 h TSD with caffeine administration at different doses. In a retrospective analysis, we replicated the finding that the A allele of TNFα G308A, found in 4 of 12 study participants, confers resilience to performance impairment during TSD. There was no evidence of an interaction of TNFα genotype with the beneficial effect of caffeine (200 or 300 mg) on performance during TSD, suggesting distinct underlying mechanisms.",

keywords = "caffeine gum, Cognitive impairment, dose response, fatigue, phenotype, psychomotor vigilance test (PVT), single nucleotide polymorphism, within-subjects design",

author = "Lillian Skeiky and Brager, {Allison J.} and Satterfield, {Brieann C.} and Martha Petrovick and Balkin, {Thomas J.} and Capaldi, {Vincent F.} and Ratcliffe, {Ruthie H.} and {Van Dongen}, {Hans P.A.} and Hansen, {Devon A.}",

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year = "2020",

doi = "10.1080/07420528.2020.1821044",

language = "English",

volume = "37",

pages = "1461--1464",

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Skeiky, L, Brager, AJ, Satterfield, BC, Petrovick, M, Balkin, TJ, Capaldi, VF, Ratcliffe, RH, Van Dongen, HPA & Hansen, DA 2020, ' TNFα G308A genotype, resilience to sleep deprivation, and the effect of caffeine on psychomotor vigilance performance in a randomized, double-blind, placebo-controlled, crossover study', Chronobiology International, vol. 37, no. 9-10, pp. 1461-1464. https://doi.org/10.1080/07420528.2020.1821044

TNFα G308A genotype, resilience to sleep deprivation, and the effect of caffeine on psychomotor vigilance performance in a randomized, double-blind, placebo-controlled, crossover study. / Skeiky, Lillian; Brager, Allison J.; Satterfield, Brieann C. et al.
In: Chronobiology International, Vol. 37, No. 9-10, 2020, p. 1461-1464.

Research output: Contribution to journal › Article › peer-review

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AU - Satterfield, Brieann C.

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