TNF/TNF receptor 1-mediated apoptosis in hepatocytes

Hyun Ae Eum, Timothy R. Billiar*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations


Tumor necrosis factor (TNF)-alpha has been implicated in the induction of hepatocyte apoptosis in a variety of liver diseases including viral hepatitis, alcoholic hepatitis, ischemia/reperfusion injury, fulminant hepatic failure, cholestatic liver injury, and cancer. The binding of TNF to TNF receptor 1 (TNFR1) induces two simultaneous pathways, one leading to cell survival through NF-κB activation and the other cell death via apoptosis. How these pathways are regulated is poorly understood in hepatocytes. Emerging data suggest that there are often aspects of TNFR1-initiate signaling that are unique to hepatocyte. Here we summarize the past and present knowledge of the TNF/TNFR1 system in the liver.

Original languageEnglish
Title of host publicationAdvances in TNF Family Research
Subtitle of host publicationProceedings of the 12th International TNF Conference, 2009
EditorsDavid Wallach, Andrew Kovalenko, Marc Feldmann
Number of pages8
StatePublished - 2011
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598


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