TY - GEN
T1 - TNF/TNF receptor 1-mediated apoptosis in hepatocytes
AU - Eum, Hyun Ae
AU - Billiar, Timothy R.
PY - 2011
Y1 - 2011
N2 - Tumor necrosis factor (TNF)-alpha has been implicated in the induction of hepatocyte apoptosis in a variety of liver diseases including viral hepatitis, alcoholic hepatitis, ischemia/reperfusion injury, fulminant hepatic failure, cholestatic liver injury, and cancer. The binding of TNF to TNF receptor 1 (TNFR1) induces two simultaneous pathways, one leading to cell survival through NF-κB activation and the other cell death via apoptosis. How these pathways are regulated is poorly understood in hepatocytes. Emerging data suggest that there are often aspects of TNFR1-initiate signaling that are unique to hepatocyte. Here we summarize the past and present knowledge of the TNF/TNFR1 system in the liver.
AB - Tumor necrosis factor (TNF)-alpha has been implicated in the induction of hepatocyte apoptosis in a variety of liver diseases including viral hepatitis, alcoholic hepatitis, ischemia/reperfusion injury, fulminant hepatic failure, cholestatic liver injury, and cancer. The binding of TNF to TNF receptor 1 (TNFR1) induces two simultaneous pathways, one leading to cell survival through NF-κB activation and the other cell death via apoptosis. How these pathways are regulated is poorly understood in hepatocytes. Emerging data suggest that there are often aspects of TNFR1-initiate signaling that are unique to hepatocyte. Here we summarize the past and present knowledge of the TNF/TNFR1 system in the liver.
UR - http://www.scopus.com/inward/record.url?scp=79954444964&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-6612-4_65
DO - 10.1007/978-1-4419-6612-4_65
M3 - Conference contribution
C2 - 21153368
AN - SCOPUS:79954444964
SN - 9781441966117
T3 - Advances in Experimental Medicine and Biology
SP - 617
EP - 624
BT - Advances in TNF Family Research
A2 - Wallach, David
A2 - Kovalenko, Andrew
A2 - Feldmann, Marc
ER -