Tocopherol succinate: Modulation of antioxidant enzymes and oncogene expression, and hematopoietic recovery

Vijay K. Singh, Vaishali I. Parekh, Darren S. Brown, Tzu Cheg Kao, Steven R. Mog

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Purpose: A class of naturally occurring isoforms of tocopherol (tocols) was shown to have varying degrees of protection when administered before radiation exposure. We recently demonstrated that α-tocopherol succinate (TS) is a potential radiation prophylactic agent. Our objective in this study was to further investigate the mechanism of action of TS in mice exposed to 60Co γ-radiation. Methods and Materials: We evaluated the effects of TS on expression of antioxidant enzymes and oncogenes by quantitative RT-PCR in bone marrow cells of 60Co γ-irradiated mice. Further, we tested the ability of TS to rescue and repopulate hematopoietic stem cells by analyzing bone marrow cellularity and spleen colony forming unit in spleen of TS-injected and irradiated mice. Results: Our results demonstrate that TS modulated the expression of antioxidant enzymes and inhibited expression of oncogenes in irradiated mice at different time points. TS also increased colony forming unit - spleen numbers and bone marrow cellularity in irradiated mice. Conclusions: Results provide additional support for the observed radioprotective efficacy of TS and insight into mechanisms.

Original languageEnglish
Pages (from-to)571-578
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number2
StatePublished - 1 Feb 2011
Externally publishedYes


  • Antioxidant enzymes
  • Colony-forming unit - spleen
  • Mice
  • Oncogenes
  • Tocopherol succinate


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