Tolerance: Is it achievable in pediatric solid organ transplantation?

Jonathan P. Pearl, Edwin Preston, Allan D. Kirk*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Significant advances have been made in the understanding of allograft rejection. There is growing awareness that allograft acceptance, or tolerance, is also an active process rather than a passive absence of rejection. Mechanistic awareness of this process has spawned many preclinical strategies for the prevention of allograft rejection without the need for chronic immunosuppression. These therapies are currently entering clinical trials. This article reviews the prevailing therapies that hold promise for future clinical application. In particular, their application in children is discussed, as are biologic aspects of childhood immunity that may play a role in the success or failure of these strategies.

Original languageEnglish
Pages (from-to)1261-1281
Number of pages21
JournalPediatric Clinics of North America
Issue number6
StatePublished - Dec 2003
Externally publishedYes


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