Topical advances in wound care

Alexander Stojadinovic*, Jay W. Carlson, Gregory S. Schultz, Thomas A. Davis, Eric A. Elster

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


There are fundamental differences between acute wounds that proceed to uncomplicated healing and those that become chronic wounds. Non-healing or chronic wounds can result from a combination of overlapping factors that prevent healing, including local tissue ischemia, repetitive trauma and ischemia/reperfusion injury, presence of tissue necrosis, impaired cellular and systemic host response to stress, and critical bacterial contamination. The bacterial burden in the wound contributes to a sustained inflammatory state, which inhibits normal progression to the proliferative phase of healing, thereby preventing restoration of tissue integrity. Appropriate wound bed preparation removes local barriers to healing and optimizes the tissue environment to achieve wound healing. It is an essential element of wound management that advances endogenous healing as well as the efficacy of topical and other wound therapy. This article will summarize a systematic approach to wound bed preparation using the "TIME" principle, and will highlight important advances in topical wound care.

Original languageEnglish
Pages (from-to)S70-S80
JournalGynecologic Oncology
Issue number2 SUPPL.
StatePublished - Nov 2008


  • Chronic wound
  • Wound bed preparation
  • Wound healing


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