TOTAL-BODY MAGNESIUM EXCESS IN CHRONIC RENAL FAILURE

Sebastian R. Contiguglia; Allen C. Alfrey; Nancy Miller; Donald Butkus

doi:10.1016/S0140-6736(72)91032-X

TOTAL-BODY MAGNESIUM EXCESS IN CHRONIC RENAL FAILURE

Sebastian R. Contiguglia^*, Allen C. Alfrey, Nancy Miller, Donald Butkus

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Soft tissue and bone (cortical and trabecular) in thirty-three uræmic patients and eleven non-uræmic controls were analysed for magnesium to determine body stores. The mean magnesium concentration in myocardium, lung, and skin was significantly higher in the uræmic group. Skeletal-muscle and liver-magnesium concentration was not different in the two groups. Tissues containing the most consistently raised magnesium levels in uræmic patients were red blood-cells and bone. Redblood-cell magnesium levels were above the normal range in nineteen of the twenty-two uræmic patients studied. The magnesium content of both cortical and trabecular bone was increased by 66%. The mean cortical-bone magnesium (in meq. per kg. ashed weight) was 586 in the uræmic group and 340 in the controls. This study shows that patients with chronic renal failure have increased total-body magnesium, with bone being the major reservoir.

Original language	English
Pages (from-to)	1300-1302
Number of pages	3
Journal	The Lancet
Volume	299
Issue number	7764
DOIs	https://doi.org/10.1016/S0140-6736(72)91032-X
State	Published - 17 Jun 1972
Externally published	Yes

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title = "TOTAL-BODY MAGNESIUM EXCESS IN CHRONIC RENAL FAILURE",

abstract = "Soft tissue and bone (cortical and trabecular) in thirty-three ur{\ae}mic patients and eleven non-ur{\ae}mic controls were analysed for magnesium to determine body stores. The mean magnesium concentration in myocardium, lung, and skin was significantly higher in the ur{\ae}mic group. Skeletal-muscle and liver-magnesium concentration was not different in the two groups. Tissues containing the most consistently raised magnesium levels in ur{\ae}mic patients were red blood-cells and bone. Redblood-cell magnesium levels were above the normal range in nineteen of the twenty-two ur{\ae}mic patients studied. The magnesium content of both cortical and trabecular bone was increased by 66%. The mean cortical-bone magnesium (in meq. per kg. ashed weight) was 586 in the ur{\ae}mic group and 340 in the controls. This study shows that patients with chronic renal failure have increased total-body magnesium, with bone being the major reservoir.",

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AU - Contiguglia, Sebastian R.

AU - Alfrey, Allen C.

AU - Miller, Nancy

AU - Butkus, Donald

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Y1 - 1972/6/17

N2 - Soft tissue and bone (cortical and trabecular) in thirty-three uræmic patients and eleven non-uræmic controls were analysed for magnesium to determine body stores. The mean magnesium concentration in myocardium, lung, and skin was significantly higher in the uræmic group. Skeletal-muscle and liver-magnesium concentration was not different in the two groups. Tissues containing the most consistently raised magnesium levels in uræmic patients were red blood-cells and bone. Redblood-cell magnesium levels were above the normal range in nineteen of the twenty-two uræmic patients studied. The magnesium content of both cortical and trabecular bone was increased by 66%. The mean cortical-bone magnesium (in meq. per kg. ashed weight) was 586 in the uræmic group and 340 in the controls. This study shows that patients with chronic renal failure have increased total-body magnesium, with bone being the major reservoir.

AB - Soft tissue and bone (cortical and trabecular) in thirty-three uræmic patients and eleven non-uræmic controls were analysed for magnesium to determine body stores. The mean magnesium concentration in myocardium, lung, and skin was significantly higher in the uræmic group. Skeletal-muscle and liver-magnesium concentration was not different in the two groups. Tissues containing the most consistently raised magnesium levels in uræmic patients were red blood-cells and bone. Redblood-cell magnesium levels were above the normal range in nineteen of the twenty-two uræmic patients studied. The magnesium content of both cortical and trabecular bone was increased by 66%. The mean cortical-bone magnesium (in meq. per kg. ashed weight) was 586 in the uræmic group and 340 in the controls. This study shows that patients with chronic renal failure have increased total-body magnesium, with bone being the major reservoir.

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TOTAL-BODY MAGNESIUM EXCESS IN CHRONIC RENAL FAILURE

Abstract

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