Tracking the re-emergence of epidemic chikungunya virus in Indonesia

Kanti Laras; Nono C. Sukri; Ria P. Larasati; Michael J. Bangs; Rizal Kosim; A. Djauzi; Tony Wandra; John Master; Herman Kosasih; Sri Hartati; Charmagne Beckett; Endang R. Sedyaningsih; H. James Beecham; Andrew L. Corwin

doi:10.1016/j.trstmh.2004.03.013

Tracking the re-emergence of epidemic chikungunya virus in Indonesia

Kanti Laras, Nono C. Sukri, Ria P. Larasati, Michael J. Bangs, Rizal Kosim, A. Djauzi, Tony Wandra, John Master, Herman Kosasih, Sri Hartati, Charmagne Beckett, Endang R. Sedyaningsih, H. James Beecham, Andrew L. Corwin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

214 Scopus citations

Abstract

Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed by serological/virological methods. Detailed epidemiological profiles of two investigated outbreaks in Bogor and Bekasi are presented. Human sera were screened using an ELISA for IgM and IgG anti-CHIK antibodies. Additionally, reverse transcriptase PCR and virus isolation were attempted for virus identification. The mean age of cases was 37 ± 18 years in Bogor and 33 ± 20 years in Bekasi. There was no outstanding case-clustering, although outbreak-affected households were observed to be geographically grouped within villages. The attack rates in Bogor and Bekasi were 2.8/1000 and 6.7/1000 inhabitants respectively. Both outbreaks started in the rainy season following increased Aedes aegypti and A. albopictus densities.

Original language	English
Pages (from-to)	128-141
Number of pages	14
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	99
Issue number	2
DOIs	https://doi.org/10.1016/j.trstmh.2004.03.013
State	Published - Feb 2005
Externally published	Yes

Keywords

Chikungunya virus
Epidemic
Indonesia

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10.1016/j.trstmh.2004.03.013

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Laras, K., Sukri, N. C., Larasati, R. P., Bangs, M. J., Kosim, R., Djauzi, A., Wandra, T., Master, J., Kosasih, H., Hartati, S., Beckett, C., Sedyaningsih, E. R., Beecham, H. J., & Corwin, A. L. (2005). Tracking the re-emergence of epidemic chikungunya virus in Indonesia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 99(2), 128-141. https://doi.org/10.1016/j.trstmh.2004.03.013

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title = "Tracking the re-emergence of epidemic chikungunya virus in Indonesia",

abstract = "Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed by serological/virological methods. Detailed epidemiological profiles of two investigated outbreaks in Bogor and Bekasi are presented. Human sera were screened using an ELISA for IgM and IgG anti-CHIK antibodies. Additionally, reverse transcriptase PCR and virus isolation were attempted for virus identification. The mean age of cases was 37 ± 18 years in Bogor and 33 ± 20 years in Bekasi. There was no outstanding case-clustering, although outbreak-affected households were observed to be geographically grouped within villages. The attack rates in Bogor and Bekasi were 2.8/1000 and 6.7/1000 inhabitants respectively. Both outbreaks started in the rainy season following increased Aedes aegypti and A. albopictus densities.",

keywords = "Chikungunya virus, Epidemic, Indonesia",

author = "Kanti Laras and Sukri, {Nono C.} and Larasati, {Ria P.} and Bangs, {Michael J.} and Rizal Kosim and A. Djauzi and Tony Wandra and John Master and Herman Kosasih and Sri Hartati and Charmagne Beckett and Sedyaningsih, {Endang R.} and Beecham, {H. James} and Corwin, {Andrew L.}",

note = "Funding Information: This work received financial support from the US Department of Defense and the Global Emerging Infections System (GEIS).",

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Laras, K, Sukri, NC, Larasati, RP, Bangs, MJ, Kosim, R, Djauzi, A, Wandra, T, Master, J, Kosasih, H, Hartati, S, Beckett, C, Sedyaningsih, ER, Beecham, HJ & Corwin, AL 2005, 'Tracking the re-emergence of epidemic chikungunya virus in Indonesia', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 99, no. 2, pp. 128-141. https://doi.org/10.1016/j.trstmh.2004.03.013

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AU - Laras, Kanti

AU - Sukri, Nono C.

AU - Larasati, Ria P.

AU - Bangs, Michael J.

AU - Kosim, Rizal

AU - Djauzi, A.

AU - Wandra, Tony

AU - Master, John

AU - Kosasih, Herman

AU - Hartati, Sri

AU - Beckett, Charmagne

AU - Sedyaningsih, Endang R.

AU - Beecham, H. James

AU - Corwin, Andrew L.

N1 - Funding Information: This work received financial support from the US Department of Defense and the Global Emerging Infections System (GEIS).

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AB - Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed by serological/virological methods. Detailed epidemiological profiles of two investigated outbreaks in Bogor and Bekasi are presented. Human sera were screened using an ELISA for IgM and IgG anti-CHIK antibodies. Additionally, reverse transcriptase PCR and virus isolation were attempted for virus identification. The mean age of cases was 37 ± 18 years in Bogor and 33 ± 20 years in Bekasi. There was no outstanding case-clustering, although outbreak-affected households were observed to be geographically grouped within villages. The attack rates in Bogor and Bekasi were 2.8/1000 and 6.7/1000 inhabitants respectively. Both outbreaks started in the rainy season following increased Aedes aegypti and A. albopictus densities.

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JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 2

ER -

Tracking the re-emergence of epidemic chikungunya virus in Indonesia

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Keywords

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