Tracking the re-emergence of epidemic chikungunya virus in Indonesia

Kanti Laras; Nono C. Sukri; Ria P. Larasati; Michael J. Bangs; Rizal Kosim; A. Djauzi; Tony Wandra; John Master; Herman Kosasih; Sri Hartati; Charmagne Beckett; Endang R. Sedyaningsih; H. James Beecham; Andrew L. Corwin

doi:10.1016/j.trstmh.2004.03.013

Tracking the re-emergence of epidemic chikungunya virus in Indonesia

Kanti Laras
, Nono C. Sukri
, Ria P. Larasati
, Michael J. Bangs
, Rizal Kosim
, A. Djauzi
, Tony Wandra
, John Master
, Herman Kosasih
, Sri Hartati
, Charmagne Beckett
, Endang R. Sedyaningsih
, H. James Beecham
, Andrew L. Corwin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

223 Scopus citations

Abstract

Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed by serological/virological methods. Detailed epidemiological profiles of two investigated outbreaks in Bogor and Bekasi are presented. Human sera were screened using an ELISA for IgM and IgG anti-CHIK antibodies. Additionally, reverse transcriptase PCR and virus isolation were attempted for virus identification. The mean age of cases was 37 ± 18 years in Bogor and 33 ± 20 years in Bekasi. There was no outstanding case-clustering, although outbreak-affected households were observed to be geographically grouped within villages. The attack rates in Bogor and Bekasi were 2.8/1000 and 6.7/1000 inhabitants respectively. Both outbreaks started in the rainy season following increased Aedes aegypti and A. albopictus densities.

Original language	English
Pages (from-to)	128-141
Number of pages	14
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	99
Issue number	2
DOIs	https://doi.org/10.1016/j.trstmh.2004.03.013
State	Published - Feb 2005
Externally published	Yes

Keywords

Chikungunya virus
Epidemic
Indonesia

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10.1016/j.trstmh.2004.03.013

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Laras, K., Sukri, N. C., Larasati, R. P., Bangs, M. J., Kosim, R., Djauzi, A., Wandra, T., Master, J., Kosasih, H., Hartati, S., Beckett, C., Sedyaningsih, E. R., Beecham, H. J., & Corwin, A. L. (2005). Tracking the re-emergence of epidemic chikungunya virus in Indonesia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 99(2), 128-141. https://doi.org/10.1016/j.trstmh.2004.03.013

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title = "Tracking the re-emergence of epidemic chikungunya virus in Indonesia",

abstract = "Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed by serological/virological methods. Detailed epidemiological profiles of two investigated outbreaks in Bogor and Bekasi are presented. Human sera were screened using an ELISA for IgM and IgG anti-CHIK antibodies. Additionally, reverse transcriptase PCR and virus isolation were attempted for virus identification. The mean age of cases was 37 ± 18 years in Bogor and 33 ± 20 years in Bekasi. There was no outstanding case-clustering, although outbreak-affected households were observed to be geographically grouped within villages. The attack rates in Bogor and Bekasi were 2.8/1000 and 6.7/1000 inhabitants respectively. Both outbreaks started in the rainy season following increased Aedes aegypti and A. albopictus densities.",

keywords = "Chikungunya virus, Epidemic, Indonesia",

author = "Kanti Laras and Sukri, \{Nono C.\} and Larasati, \{Ria P.\} and Bangs, \{Michael J.\} and Rizal Kosim and A. Djauzi and Tony Wandra and John Master and Herman Kosasih and Sri Hartati and Charmagne Beckett and Sedyaningsih, \{Endang R.\} and Beecham, \{H. James\} and Corwin, \{Andrew L.\}",

note = "Funding Information: This work received financial support from the US Department of Defense and the Global Emerging Infections System (GEIS).",

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doi = "10.1016/j.trstmh.2004.03.013",

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Laras, K, Sukri, NC, Larasati, RP, Bangs, MJ, Kosim, R, Djauzi, A, Wandra, T, Master, J, Kosasih, H, Hartati, S, Beckett, C, Sedyaningsih, ER, Beecham, HJ & Corwin, AL 2005, 'Tracking the re-emergence of epidemic chikungunya virus in Indonesia', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 99, no. 2, pp. 128-141. https://doi.org/10.1016/j.trstmh.2004.03.013

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AU - Laras, Kanti

AU - Sukri, Nono C.

AU - Larasati, Ria P.

AU - Bangs, Michael J.

AU - Kosim, Rizal

AU - Djauzi, A.

AU - Wandra, Tony

AU - Master, John

AU - Kosasih, Herman

AU - Hartati, Sri

AU - Beckett, Charmagne

AU - Sedyaningsih, Endang R.

AU - Beecham, H. James

AU - Corwin, Andrew L.

N1 - Funding Information: This work received financial support from the US Department of Defense and the Global Emerging Infections System (GEIS).

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N2 - Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed by serological/virological methods. Detailed epidemiological profiles of two investigated outbreaks in Bogor and Bekasi are presented. Human sera were screened using an ELISA for IgM and IgG anti-CHIK antibodies. Additionally, reverse transcriptase PCR and virus isolation were attempted for virus identification. The mean age of cases was 37 ± 18 years in Bogor and 33 ± 20 years in Bekasi. There was no outstanding case-clustering, although outbreak-affected households were observed to be geographically grouped within villages. The attack rates in Bogor and Bekasi were 2.8/1000 and 6.7/1000 inhabitants respectively. Both outbreaks started in the rainy season following increased Aedes aegypti and A. albopictus densities.

AB - Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed by serological/virological methods. Detailed epidemiological profiles of two investigated outbreaks in Bogor and Bekasi are presented. Human sera were screened using an ELISA for IgM and IgG anti-CHIK antibodies. Additionally, reverse transcriptase PCR and virus isolation were attempted for virus identification. The mean age of cases was 37 ± 18 years in Bogor and 33 ± 20 years in Bekasi. There was no outstanding case-clustering, although outbreak-affected households were observed to be geographically grouped within villages. The attack rates in Bogor and Bekasi were 2.8/1000 and 6.7/1000 inhabitants respectively. Both outbreaks started in the rainy season following increased Aedes aegypti and A. albopictus densities.

KW - Chikungunya virus

KW - Epidemic

KW - Indonesia

UR - https://www.scopus.com/pages/publications/19944409886

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VL - 99

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JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 2

ER -

Tracking the re-emergence of epidemic chikungunya virus in Indonesia

Abstract

Keywords

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