Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation

David O. Okonkwo; Jaime Wagner; David E. Melon; Tord Alden; James R. Stone; Gregory A. Helm; John A. Jane

doi:10.1016/j.neulet.2003.08.044

Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation

David O. Okonkwo^*, Jaime Wagner, David E. Melon, Tord Alden, James R. Stone, Gregory A. Helm, John A. Jane

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Trans-sodium crocetinate (TSC) is a vitamin A-analog that increases diffusivity of oxygen in aqueous solutions, including plasma. The current study is the initial investigation of the effects of TSC on oxygen delivery to brain. Adult male rats were intubated and ventilated with 21%, 60%, or 100% oxygen. A craniotomy was performed and a Licox rat brain tissue PO₂ probe inserted into parietal cortex. Rats were then administered intravenous infusions of either TSC or saline and brain tissue PO₂ values were recorded. TSC significantly increased brain tissue oxygen delivery. This effect was minimal in rats ventilated with normal air and substantial in rats on oxygen supplementation. Arterial blood gas parameters did not differ within groups. These results provide clear indication to study the utility of TSC in ameliorating hypoxic/ischemic insults in neurological disorders.

Original language	English
Pages (from-to)	97-100
Number of pages	4
Journal	Neuroscience Letters
Volume	352
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2003.08.044
State	Published - 11 Dec 2003
Externally published	Yes

Keywords

Brain metabolism
Brain tissue oxygenation
Cerebral ischemia
Hyperoxia
Hypoxia
Trans-sodium crocetinate

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title = "Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation",

abstract = "Trans-sodium crocetinate (TSC) is a vitamin A-analog that increases diffusivity of oxygen in aqueous solutions, including plasma. The current study is the initial investigation of the effects of TSC on oxygen delivery to brain. Adult male rats were intubated and ventilated with 21%, 60%, or 100% oxygen. A craniotomy was performed and a Licox rat brain tissue PO2 probe inserted into parietal cortex. Rats were then administered intravenous infusions of either TSC or saline and brain tissue PO2 values were recorded. TSC significantly increased brain tissue oxygen delivery. This effect was minimal in rats ventilated with normal air and substantial in rats on oxygen supplementation. Arterial blood gas parameters did not differ within groups. These results provide clear indication to study the utility of TSC in ameliorating hypoxic/ischemic insults in neurological disorders.",

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AU - Okonkwo, David O.

AU - Wagner, Jaime

AU - Melon, David E.

AU - Alden, Tord

AU - Stone, James R.

AU - Helm, Gregory A.

AU - Jane, John A.

PY - 2003/12/11

Y1 - 2003/12/11

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KW - Brain metabolism

KW - Brain tissue oxygenation

KW - Cerebral ischemia

KW - Hyperoxia

KW - Hypoxia

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ER -

Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation

Abstract

Keywords

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