Transjugular renal biopsy in high-risk patients: An American case series

Kevin C. Abbott*, Franco M. Musio, Ellen M. Chung, Nick N. Lomis, John D. Lane, Christina M. Yuan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Background: In the United States, transjugular renal biopsies using the Quickcore™ side cut needle system have previously been described primarily for transjugular renal biopsy in patients with concurrent liver and kidney disease. Methods: We describe transjugular renal biopsy with the Quickcore™ system in 9 patients with nephrotic syndrome and contraindications to percutaneous renal biopsy, who underwent biopsy between 23 October 1996 and 12 April 2001. The most common contraindication was oral anticoagulation with coumadin (40%). Other contraindications included horseshoe kidney, severe renal failure, and spontaneous coagulopathy. A 62 cm straight catheter and 60 cm side-cut Quickcore™ biopsy needle were used to obtain cortical tissue. Packing of the biopsy tract with Gelfoam™ was used for venographically identified capsular perforation. Results: Ten procedures were performed on 9 patients with one requiring re-biopsy (5% of all renal biopsies performed at our institution). There were 9 transjugular renal biopsy and one combined liver-kidney biopsy. A mean of 4 ± 2 passes were made, with a mean of 3 ± 1 cores obtained per procedure. Histologic diagnosis was made in 90% of biopsies and in 100% of patients. Two patients developed transient hydronephrosis associated with gross hematuria; both required transfusion. Capsular perforation occurred in 90%. One patient died of bacterial sepsis, unrelated to the biopsy, several days after the procedure. Conclusions: Transjugular renal biopsy appears to be efficacious in high-risk patients, for whom the percutaneous approach is contraindicated, including patients on oral anticoagulation. The transfusion rate in the present study was similar to other American reports using this technique.

Original languageEnglish
Article number5
Pages (from-to)1-6
Number of pages6
JournalBMC Nephrology
StatePublished - 11 Jul 2002
Externally publishedYes


  • Anticoagulation
  • Horseshoe kidney
  • Kidney
  • Liver
  • Renal failure
  • Transjugular renal biopsy


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