Transplantation for metastatic colorectal cancer to liver

Shekhar Gogna; Priya Goyal; Jason Hawksworth; Aiwu Ruth He

doi:10.1016/B978-0-443-21901-6.00005-7

Transplantation for metastatic colorectal cancer to liver

Shekhar Gogna, Priya Goyal, Jason Hawksworth, Aiwu Ruth He

Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Liver transplant can offer improved overall survival in patients with nonresectable colorectal liver metastases attributed to enhanced multidisciplinary care and better patient selection and management of post-transplant immunosuppression. The Fong score, the Oslo score, PET MTV liver uptake values, tumor location (right-sided or not), histological differentiation, lymph node status of the primary cancer, and tumor genetic mutations all contribute to the outcome of patients receiving liver transplantation for nCRLM. The marginal allografts (grafts from donors with extended criteria) offered inferior outcomes but have been improving over the last 2decades, trending toward those seen with the “perfect” liver allograft.

Original language	English
Title of host publication	Transplant Oncology
Subtitle of host publication	A Frontier in Multidisciplinary Cancer Care
Publisher	Elsevier
Pages	51-62
Number of pages	12
ISBN (Electronic)	9780443219016
ISBN (Print)	9780443219023
DOIs	https://doi.org/10.1016/B978-0-443-21901-6.00005-7
State	Published - 1 Jan 2024

Keywords

Colorectal cancer
Colorectal liver metastases
Disease free survival
Liver transplantation
Organ donation
Overall survival
Recurrence

Access to Document

10.1016/B978-0-443-21901-6.00005-7

Cite this

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title = "Transplantation for metastatic colorectal cancer to liver",

abstract = "Liver transplant can offer improved overall survival in patients with nonresectable colorectal liver metastases attributed to enhanced multidisciplinary care and better patient selection and management of post-transplant immunosuppression. The Fong score, the Oslo score, PET MTV liver uptake values, tumor location (right-sided or not), histological differentiation, lymph node status of the primary cancer, and tumor genetic mutations all contribute to the outcome of patients receiving liver transplantation for nCRLM. The marginal allografts (grafts from donors with extended criteria) offered inferior outcomes but have been improving over the last 2decades, trending toward those seen with the “perfect” liver allograft.",

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AU - Goyal, Priya

AU - Hawksworth, Jason

AU - He, Aiwu Ruth

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AB - Liver transplant can offer improved overall survival in patients with nonresectable colorectal liver metastases attributed to enhanced multidisciplinary care and better patient selection and management of post-transplant immunosuppression. The Fong score, the Oslo score, PET MTV liver uptake values, tumor location (right-sided or not), histological differentiation, lymph node status of the primary cancer, and tumor genetic mutations all contribute to the outcome of patients receiving liver transplantation for nCRLM. The marginal allografts (grafts from donors with extended criteria) offered inferior outcomes but have been improving over the last 2decades, trending toward those seen with the “perfect” liver allograft.

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KW - Colorectal liver metastases

KW - Disease free survival

KW - Liver transplantation

KW - Organ donation

KW - Overall survival

KW - Recurrence

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