Transporter pharmacogenetics: Transporter polymorphisms affect normal physiology, diseases, and pharmacotherapy

Tristan M. Sissung*, Sarah M. Troutman, Tessa J. Campbell, Heather M. Pressler, Hyeyoung Sung, Susan E. Bates, William D. Figg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Drug transporters mediate the movement of endobiotics and xenobiotics across biological membranes in multiple organs and in most tissues. As such, they are involved in physiology, development of disease, drug pharmacokinetics, and ultimately the clinical response to a myriad of medications. Genetic variants in transporters cause population-specific differences in drug transport and are responsible for considerable inter-individual variation in physiology and pharmacotherapy. The purpose of this review is to provide a broad overview of how inherited variants in transporters are associated with disease etiology, disease state, and the pharmacological treatment of diseases. Given that there are thousands of published papers related to the interplay between transporter genetics and medicine, this review will provide examples that exemplify the broader focus of the literature.

Original languageEnglish
Pages (from-to)19-34
Number of pages16
JournalDiscovery Medicine
Volume13
Issue number68
StatePublished - Jan 2013
Externally publishedYes

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