Treating clostridium difficile infection with fecal microbiota transplantation

Johan S. Bakken, Thomas Borody, Lawrence J. Brandt, Joel V. Brill, Daniel C. Demarco, Marc Alaric Franzos, Colleen Kelly, Alexander Khoruts, Thomas Louie, Lawrence P. Martinelli, Thomas A. Moore*, George Russell, Christina Surawicz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

765 Scopus citations


Clostridium difficile infection is increasing in incidence, severity, and mortality. Treatment options are limited and appear to be losing efficacy. Recurrent disease is especially challenging; extended treatment with oral vancomycin is becoming increasingly common but is expensive. Fecal microbiota transplantation is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured. We discuss the rationale, methods, and use of fecal microbiota transplantation.

Original languageEnglish
Pages (from-to)1044-1049
Number of pages6
JournalClinical Gastroenterology and Hepatology
Issue number12
StatePublished - Dec 2011
Externally publishedYes


  • Clostridium difficile
  • Diarrhea
  • Fecal Enema
  • Microbiota
  • Recurrent Infection
  • Transplantation


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