Treating clostridium difficile infection with fecal microbiota transplantation

Johan S. Bakken; Thomas Borody; Lawrence J. Brandt; Joel V. Brill; Daniel C. Demarco; Marc Alaric Franzos; Colleen Kelly; Alexander Khoruts; Thomas Louie; Lawrence P. Martinelli; Thomas A. Moore; George Russell; Christina Surawicz

doi:10.1016/j.cgh.2011.08.014

Treating clostridium difficile infection with fecal microbiota transplantation

Johan S. Bakken, Thomas Borody, Lawrence J. Brandt, Joel V. Brill, Daniel C. Demarco, Marc Alaric Franzos, Colleen Kelly, Alexander Khoruts, Thomas Louie, Lawrence P. Martinelli, Thomas A. Moore^*, George Russell, Christina Surawicz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

784 Scopus citations

Abstract

Clostridium difficile infection is increasing in incidence, severity, and mortality. Treatment options are limited and appear to be losing efficacy. Recurrent disease is especially challenging; extended treatment with oral vancomycin is becoming increasingly common but is expensive. Fecal microbiota transplantation is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured. We discuss the rationale, methods, and use of fecal microbiota transplantation.

Original language	English
Pages (from-to)	1044-1049
Number of pages	6
Journal	Clinical Gastroenterology and Hepatology
Volume	9
Issue number	12
DOIs	https://doi.org/10.1016/j.cgh.2011.08.014
State	Published - Dec 2011
Externally published	Yes

Keywords

Clostridium difficile
Diarrhea
Fecal Enema
Microbiota
Recurrent Infection
Transplantation

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10.1016/j.cgh.2011.08.014

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Bakken, J. S., Borody, T., Brandt, L. J., Brill, J. V., Demarco, D. C., Franzos, M. A., Kelly, C., Khoruts, A., Louie, T., Martinelli, L. P., Moore, T. A., Russell, G., & Surawicz, C. (2011). Treating clostridium difficile infection with fecal microbiota transplantation. Clinical Gastroenterology and Hepatology, 9(12), 1044-1049. https://doi.org/10.1016/j.cgh.2011.08.014

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title = "Treating clostridium difficile infection with fecal microbiota transplantation",

abstract = "Clostridium difficile infection is increasing in incidence, severity, and mortality. Treatment options are limited and appear to be losing efficacy. Recurrent disease is especially challenging; extended treatment with oral vancomycin is becoming increasingly common but is expensive. Fecal microbiota transplantation is safe, inexpensive, and effective; according to case and small series reports, about 90% of patients are cured. We discuss the rationale, methods, and use of fecal microbiota transplantation.",

keywords = "Clostridium difficile, Diarrhea, Fecal Enema, Microbiota, Recurrent Infection, Transplantation",

author = "Bakken, {Johan S.} and Thomas Borody and Brandt, {Lawrence J.} and Brill, {Joel V.} and Demarco, {Daniel C.} and Franzos, {Marc Alaric} and Colleen Kelly and Alexander Khoruts and Thomas Louie and Martinelli, {Lawrence P.} and Moore, {Thomas A.} and George Russell and Christina Surawicz",

note = "Funding Information: Conflicts of interest These authors disclose the following: Thomas Borody has patents in the field of fecal transplantation. Alexander Khoruts receives funding from the Minnesota Medical Foundation and NIH grant 1R21AI091907 . The remaining authors disclose no conflicts. ",

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AU - Bakken, Johan S.

AU - Borody, Thomas

AU - Brandt, Lawrence J.

AU - Brill, Joel V.

AU - Demarco, Daniel C.

AU - Franzos, Marc Alaric

AU - Kelly, Colleen

AU - Khoruts, Alexander

AU - Louie, Thomas

AU - Martinelli, Lawrence P.

AU - Moore, Thomas A.

AU - Russell, George

AU - Surawicz, Christina

N1 - Funding Information: Conflicts of interest These authors disclose the following: Thomas Borody has patents in the field of fecal transplantation. Alexander Khoruts receives funding from the Minnesota Medical Foundation and NIH grant 1R21AI091907 . The remaining authors disclose no conflicts.

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Treating clostridium difficile infection with fecal microbiota transplantation

Abstract

Keywords

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