Treatment-resistant cough: A rare manifestation of IgG4-related disease involving the larynx

Azfar Shahid Syed*, Rhonda E. Colombo, Bakhtiar S. Syed, Peter M. Henning

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


IgG4-related autoimmune diseases (IgG4 RD) are a relatively recently recognised group of disease processes that can affect multiple organ systems and result in protean symptoms. Here, we present a rare case of a 69-year-old man with a history of IgG4 RD affecting his lacrimal gland and pancreas who developed symptoms of severe laryngitis not responsive to usual therapy. He presented with non-productive cough, hoarseness and dyspnoea. Imaging findings suggestive of aortitis and laryngeal inflammation in the setting of his IgG4 RD history prompted treatment with rituximab, which resulted in resolution of his laryngeal symptoms. Subsequently, his cough returned and he required periodic rituximab infusions to stay symptom-free. IgG4 RD of the larynx is an uncommonly reported manifestation in literature. This disease is very responsive to anti-CD20 monoclonal antibody treatment. IgG4 RD should be considered in patients with airway symptoms that are especially refractory to usual therapy.

Original languageEnglish
Article number237614
JournalBMJ Case Reports
Issue number11
StatePublished - 23 Nov 2020
Externally publishedYes


  • ear
  • nose and throat
  • rheumatology


Dive into the research topics of 'Treatment-resistant cough: A rare manifestation of IgG4-related disease involving the larynx'. Together they form a unique fingerprint.

Cite this